Article · Wikipedia archive · Last revised Jul 26, 2026

MM-77

MM-77 is a piperazine derivative which is a serotonergic drug, acting as a potent and selective 5-HT1A receptor antagonist. It is used for research into the 5-HT1A receptor and has anxiolytic effects in animal models.

Last revised
Jul 26, 2026
Read time
≈ 1 min
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271 w
Citations
6
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Wikipedia ↗
MM-77
Clinical data
Drug classSerotonin 5-HT1A receptor antagonist
ATC code
  • None
Identifiers
  • 1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrrolidine-2,5-dione
CAS Number
PubChem CID
Chemical and physical data
FormulaC19H27N3O3
Molar mass345.443 g·mol−1
3D model (JSmol)
  • COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)CCC3=O
  • InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3
  • Key:MQHOGPLXAXSQAJ-UHFFFAOYSA-N

MM-77 is a piperazine derivative which is a serotonergic drug, acting as a potent and selective 5-HT1A receptor antagonist. It is used for research into the 5-HT1A receptor and has anxiolytic effects in animal models.123456

See also

See also

References

References

  1. Griebel G, Rodgers RJ, Perrault G, Sanger DJ (May 1999). "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology. 144 (2): 121–130. doi:10.1007/s002130050984. PMID 10394992.
  2. Griebel G, Rodgers RJ, Perrault G, Sanger DJ (July 2000). "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology. 39 (10): 1848–1857. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565.
  3. Wesołowska A, Paluchowska M, Chojnacka-Wójcik E (June 2003). "Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists". European Journal of Pharmacology. 471 (1): 27–34. doi:10.1016/s0014-2999(03)01814-4. PMID 12809949.
  4. Bojarski AJ, Duszyńska B, Kołaczkowski M, Kowalski P, Kowalska T (December 2004). "The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands". Bioorganic & Medicinal Chemistry Letters. 14 (23): 5863–5866. doi:10.1016/j.bmcl.2004.09.029. PMID 15501057.
  5. Alfredo BA, Ofir P (January 2005). "Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents". European Journal of Pharmacology. 508 (1–3): 155–158. doi:10.1016/j.ejphar.2004.12.013. PMID 15680266.
  6. Briones-Aranda A, Castillo-Salazar M, Picazo O (March 2009). "Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats". Pharmacology, Biochemistry, and Behavior. 92 (1): 182–189. doi:10.1016/j.pbb.2008.11.008. PMID 19095004.