Michael Griffiths or Mike Griffiths may refer to:
- Michael Griffiths (cabaret artist), Australian cabaret performer, winner of 2016 Helpmann Award for Best Cabaret Performer
- Michael Griffiths (TV personality), British contestant on Love Island, s.5 in 2019
- Michael Ambrose Griffiths, English Roman Catholic bishop
- Mike Griffiths, Welsh rugby union player
- Mike Griffiths (British Army officer) a retired British police officer