MEPE

Available protein structures:
PDB	IPR009837 PF07175 (ECOD; PDBsum)
AlphaFold	IPR009837; PF07175;

Osteoregulin
Osteoregulin
Identifiers
Symbol	Osteoregulin
Pfam	PF07175
InterPro	IPR009837
PDB
Available protein structures:
PDB	IPR009837 PF07175 (ECOD; PDBsum)
AlphaFold	IPR009837; PF07175;

MEPE
Identifiers
Aliases	MEPE, OF45, matrix extracellular phosphoglycoprotein
External IDs	OMIM: 605912; MGI: 2137384; HomoloGene: 10623; GeneCards: MEPE; OMA:MEPE - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,846,814 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,486,477 bp
RNA expression pattern
	Top expressed in
	tibia; ; periodontal fiber; ; trabecular bone; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 23; ; Brodmann area 9; ; prefrontal cortex; ; middle temporal gyrus; ; superior frontal gyrus;
	Top expressed in
	body of femur; ; tibiofemoral joint; ; cochlea; ; fossa; ; vestibular labyrinth; ; vestibular sensory epithelium; ; efferent ductule; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding; extracellular matrix protein binding;
Cellular component	extracellular region; endoplasmic reticulum lumen; extracellular matrix;
Biological process	skeletal system development; biomineral tissue development; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	56955
	94111
	ENSG00000152595
	ENSMUSG00000053863
	Q9NQ76
	Q8K4L6
NM_001184694; NM_001184695; NM_001184696; NM_001184697; NM_001291183;
	NM_020203
	NM_053172
NP_001171623; NP_001171624; NP_001171625; NP_001171626; NP_001278112;
	NP_064588
	NP_444402
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.⁵⁶ A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.⁷

References

GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.
"Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".
Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

Further reading

Quarles LD (2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization". Am. J. Physiol. Endocrinol. Metab. 285 (1): E1–9. doi:10.1152/ajpendo.00016.2003. PMID 12791601.
Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
Jain A, Fedarko NS, Collins MT, et al. (2004). "Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density". J. Clin. Endocrinol. Metab. 89 (8): 4158–61. doi:10.1210/jc.2003-032031. PMID 15292364.
Nampei A, Hashimoto J, Hayashida K, et al. (2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone". J. Bone Miner. Metab. 22 (3): 176–84. doi:10.1007/s00774-003-0468-9. PMID 15108058. S2CID 13194013.
MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21". Connect. Tissue Res. 43 (2–3): 320–30. doi:10.1080/713713461. PMID 12489176.
Argiro L, Desbarats M, Glorieux FH, Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone". Genomics. 74 (3): 342–51. doi:10.1006/geno.2001.6553. PMID 11414762.

This article incorporates text from the public domain Pfam and InterPro: IPR009837

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945470-5] Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.

[entrez-6] "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".

[pmid10967096-7] Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

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