MEOX1

MEOX1
Identifiers
Aliases	MEOX1, KFS2, MOX1, mesenchyme homeobox 1
External IDs	OMIM: 600147; MGI: 103220; HomoloGene: 3326; GeneCards: MEOX1; OMA:MEOX1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,661,922 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,785,200 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; subcutaneous adipose tissue; ; apex of heart; ; Achilles tendon; ; parietal pleura; ; lactiferous duct; ; abdominal fat; ; synovial joint; ; synovial membrane; ; saphenous vein;
	Top expressed in
	somite; ; semi-lunar valve; ; intermediate mesoderm; ; aortic valve; ; ankle joint; ; endocardial cushion; ; sclerotome; ; interventricular septum; ; urethra; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; HMG box domain binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; molecular function; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; somite specification; transcription by RNA polymerase II; sclerotome development; transcription, DNA-templated; multicellular organism development; hematopoietic stem cell differentiation; positive regulation of transcription by RNA polymerase II; somite development; biological process;
	Sources:Amigo / QuickGO
Orthologs
	4222
	17285
	ENSG00000005102
	ENSMUSG00000001493
	P50221
	P32442
	NM_001040002; NM_004527; NM_013999
	NM_010791
	NP_001035091; NP_004518; NP_054705
	NP_034921
	Wikidata
View/Edit Human	View/Edit Mouse

Mesenchyme homeobox 1 (MEOX1) is a protein that in humans is encoded by the MEOX1 gene.⁵⁶

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing transcription factor genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.⁶

Interactions

MEOX1 has been shown to interact with PAX1⁷ and PAX3.⁷

References

GRCh38: Ensembl release 89: ENSG00000005102 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001493 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.
"Entrez Gene: MEOX1 mesenchyme homeobox 1".
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

Further reading

Jones KA, Black DM, Brown MA, Griffiths BL, Nicolai HM, Chambers JA, Bonjardim M, Xu CF, Boyd M, McFarlane R (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase". Hum. Mol. Genet. 3 (11): 1927–34. doi:10.1093/hmg/3.11.1927. PMID 7874108.
Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin". Differentiation. 62 (1): 33–41. doi:10.1046/j.1432-0436.1997.6210033.x. PMID 9373945.
Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells". J. Biol. Chem. 279 (23): 23874–81. doi:10.1074/jbc.M312612200. PMID 15039437.
Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells". J. Biol. Chem. 280 (22): 21022–8. doi:10.1074/jbc.M502977200. PMID 15793308.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005102 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001493 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7987315-5] Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.

[entrez-6] "Entrez Gene: MEOX1 mesenchyme homeobox 1".

[pmid11423130-7] Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

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