MED30

Available protein structures:
PDB	IPR021019 PF11315 (ECOD; PDBsum)
AlphaFold	IPR021019; PF11315;

Med30
Med30
Identifiers
Symbol	Med30
Pfam	PF11315
InterPro	IPR021019
PDB
Available protein structures:
PDB	IPR021019 PF11315 (ECOD; PDBsum)
AlphaFold	IPR021019; PF11315;

MED30
Identifiers
Aliases	MED30, MED30S, THRAP6, TRAP25, mediator complex subunit 30
External IDs	OMIM: 610237; MGI: 1917040; HomoloGene: 12329; GeneCards: MED30; OMA:MED30 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	117,540,262 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	52,593,960 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; bone marrow; ; monocyte; ; ganglionic eminence; ; sperm; ; testicle; ; cartilage tissue; ; Achilles tendon; ; left ovary;
	Top expressed in
	medial ganglionic eminence; ; zygote; ; interventricular septum; ; endocardial cushion; ; secondary oocyte; ; primary oocyte; ; granulocyte; ; atrioventricular valve; ; thymus; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity; vitamin D receptor binding; thyroid hormone receptor binding; nuclear receptor coactivator activity; ubiquitin protein ligase activity; protein binding; signaling receptor activity;
Cellular component	nucleoplasm; nucleus; mediator complex; ubiquitin ligase complex;
Biological process	transcription, DNA-templated; androgen receptor signaling pathway; stem cell population maintenance; intracellular steroid hormone receptor signaling pathway; positive regulation of transcription, DNA-templated; protein ubiquitination; regulation of transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	90390
	69790
	ENSG00000164758
	ENSMUSG00000038622
	Q96HR3
	Q9CQI9
	NM_001282986; NM_080651; NM_001363182
	NM_027212
	NP_001269915; NP_542382; NP_001350111
	NP_081488
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.⁵ It represents subunit Med30 of the Mediator complex and is metazoan-specific,⁶ having no homologues in yeasts.

Interactions

MED30 has been shown to interact with MED22.⁷

References

GRCh38: Ensembl release 89: ENSG00000164758 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038622 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".
Baek HJ, Malik S, Qin J, Roeder RG (April 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

Further reading

Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, et al. (June 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, et al. (February 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, et al. (December 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Wang Q, Sharma D, Ren Y, Fondell JD (November 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". The Journal of Biological Chemistry. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
Baek HJ, Malik S, Qin J, Roeder RG (April 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (April 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267. S2CID 23646963.
Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, et al. (April 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, et al. (March 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

This article incorporates text from the public domain Pfam and InterPro: IPR021019

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6".

[pmid11909976-6] Baek HJ, Malik S, Qin J, Roeder RG (April 2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s". Molecular and Cellular Biology. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976.

[pmid12584197-7] Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

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