MBOAT7

MBOAT7
Identifiers
Aliases	MBOAT7, BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, membrane bound O-acyltransferase domain containing 7, MRT57, LPLAT
External IDs	OMIM: 606048; MGI: 1924832; HomoloGene: 11510; GeneCards: MBOAT7; OMA:MBOAT7 - orthologs
EC number	2.3.1.n4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,189,882 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,696,522 bp
RNA expression pattern
	Top expressed in
	blood; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; superior frontal gyrus; ; stromal cell of endometrium; ; right frontal lobe; ; prefrontal cortex; ; hypothalamus;
	Top expressed in
	granulocyte; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; central gray substance of midbrain; ; superior frontal gyrus; ; primary visual cortex; ; nucleus of stria terminalis; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; acyltransferase activity; protein binding; 2-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophospholipid acyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; mitochondria associated membranes; endoplasmic reticulum;
Biological process	phosphatidylinositol acyl-chain remodeling; phosphatidylinositol metabolic process; ventricular system development; lipid metabolism; phospholipid biosynthetic process; phospholipid metabolic process; layer formation in cerebral cortex;
	Sources:Amigo / QuickGO
Orthologs
	79143
	77582
ENSG00000273592; ENSG00000278519; ENSG00000274194; ENSG00000125505; ENSG00000277025;
	ENSG00000275118; ENSG00000276935; ENSG00000277733; ENSG00000277923; ENSG00000278322
	ENSMUSG00000035596
	Q96N66
	Q8CHK3
	NM_001146056; NM_001146082; NM_001146083; NM_024298
	NM_029934
	NP_001139528; NP_001139554; NP_001139555; NP_077274
	NP_084210
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.⁵ It is homologous to other membrane-bound O-acyltransferases.⁶⁷

Function

This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.⁵⁶

References

ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035596 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Membrane bound O-acyltransferase domain containing 7".
Shindou H, Shimizu T (2009). "Acyl-CoA:Lysophospholipid Acyltransferases". Journal of Biological Chemistry. 284 (1): 1–5. doi:10.1074/jbc.R800046200. PMID 18718904.
Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV (2023). "The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification". Nature Communications. 14 (1) 3533: 3533. Bibcode:2023NatCo..14.3533W. doi:10.1038/s41467-023-38932-5. PMC 10267149. PMID 37316513.

Further reading

Wende H, Volz A, Ziegler A (July 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (March 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC 2262980. PMID 18094042.
Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (April 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl (Suppl): S46–51. doi:10.1194/jlr.R800035-JLR200. PMC 2674719. PMID 18931347.
Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (October 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi:10.1074/jbc.M806194200. PMC 2573059. PMID 18772128.
Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID 8702217.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".

[shindoushimizu2009-6] Shindou H, Shimizu T (2009). "Acyl-CoA:Lysophospholipid Acyltransferases". Journal of Biological Chemistry. 284 (1): 1–5. doi:10.1074/jbc.R800046200. PMID 18718904.

[7] Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV (2023). "The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification". Nature Communications. 14 (1) 3533: 3533. Bibcode:2023NatCo..14.3533W. doi:10.1038/s41467-023-38932-5. PMC 10267149. PMID 37316513.

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