Mathys is a family surname that could refer to:
Surname
- Charlie Mathys, American professional football player
- Marco Mathys, Swiss footballer
- Lucien Mathys, Belgian racing cyclist
- Maude Mathys, Swiss ski mountaineer
- Melanie Mathys, Swiss female canoeist
Other
- Mathys Bank, Antarctic rock ridge
- Mathys Zyn Loop, South African town