MARCH7

MARCHF7
Identifiers
Aliases	MARCHF7, AXO, AXOT, MARCH-VII, RNF177, membrane associated ring-CH-type finger 7, MARCH7
External IDs	OMIM: 613334; MGI: 1931053; HomoloGene: 10753; GeneCards: MARCHF7; OMA:MARCHF7 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	159,771,027 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; ventricular zone; ; gingival epithelium; ; secondary oocyte; ; oral cavity; ; germinal epithelium; ; ganglionic eminence; ; gallbladder; ; epithelium of nasopharynx;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; transferase activity; enzyme binding; ubiquitin conjugating enzyme binding; ubiquitin binding; MDM2/MDM4 family protein binding; protein binding;
Cellular component	nucleus; cytosol; plasma membrane;
Biological process	negative regulation of T cell proliferation; regulation of tolerance induction; protein ubiquitination; positive regulation of cell population proliferation; negative regulation of DNA damage response, signal transduction by p53 class mediator; protein stabilization; protein autoubiquitination; negative regulation of proteasomal protein catabolic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein polyubiquitination; negative regulation of protein autoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	64844
	57438
	ENSG00000136536
	n/a
	Q9H992
	Q9WV66
	NM_001282805; NM_001282806; NM_001282807; NM_022826
	NM_020575
NP_001269734; NP_001269735; NP_001269736; NP_073737; NP_001363163;
	NP_001363164; NP_001363165; NP_001363166; NP_001363167; NP_001363168; NP_001363169; NP_001363170; NP_001363171; NP_001363172; NP_001363173; NP_001363174; NP_001363175; NP_001363176; NP_001363177; NP_001363178; NP_001363179; NP_001363180; NP_001363181; NP_001363182; NP_001363183; NP_001363184
	NP_065600
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase MARCH7 is an enzyme that in humans is encoded by the MARCH7 gene.⁴⁵

References

GRCh38: Ensembl release 89: ENSG00000136536 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
"Entrez Gene: MARCH7 membrane-associated ring finger (C3HC4) 7".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Metcalfe SM, Muthukumarana PA, Thompson HL, et al. (2005). "Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance". FEBS Lett. 579 (3): 609–14. doi:10.1016/j.febslet.2004.12.027. PMID 15670816. S2CID 24334635.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Flierman D, Coleman CS, Pickart CM, et al. (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. Bibcode:2006PNAS..10311589F. doi:10.1073/pnas.0605215103. PMC 1520313. PMID 16868077.
Muthukumarana PA, Lyons GE, Miura Y, et al. (2007). "Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance". Int. Immunopharmacol. 6 (13–14): 1993–2001. doi:10.1016/j.intimp.2006.09.015. PMID 17161353.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136536 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14722266-4] Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.

[entrez-5] "Entrez Gene: MARCH7 membrane-associated ring finger (C3HC4) 7".

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