MAN1A2

MAN1A2
Identifiers
Aliases	MAN1A2, MAN1B, mannosidase alpha class 1A member 2
External IDs	OMIM: 604345; MGI: 104676; HomoloGene: 55982; GeneCards: MAN1A2; OMA:MAN1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,528,872 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,592,819 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; Epithelium of choroid plexus; ; Brodmann area 23; ; parietal pleura; ; epithelium of nasopharynx; ; visceral pleura; ; placenta; ; superficial temporal artery; ; skin of thigh;
	Top expressed in
	genital tubercle; ; medial dorsal nucleus; ; tail of embryo; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; molar; ; spermatocyte; ; anterior amygdaloid area; ; spermatid; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; metal ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	Golgi apparatus; extracellular exosome; endoplasmic reticulum; membrane; integral component of membrane; Golgi membrane;
Biological process	protein glycosylation; N-glycan processing; lung alveolus development; metabolism; glycoprotein metabolic process; Golgi apparatus mannose trimming; respiratory gaseous exchange by respiratory system;
	Sources:Amigo / QuickGO
Orthologs
	10905
	17156
	ENSG00000198162
	ENSMUSG00000008763
	O60476
	P39098
	NM_006699
	NM_010763
	NP_006690
	NP_034893
	Wikidata
View/Edit Human	View/Edit Mouse

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000198162 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000008763 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.
"Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".

Further reading

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211. S2CID 13576808.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Hart ML, Saifuddin M, Spear GT (2003). "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–360. doi:10.1099/vir.0.18734-0. PMID 12560567.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–195. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–7470. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–220. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–11099. doi:10.1021/bi00092a019. PMID 8218172.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–160. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–38. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID 2829950.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–169. PMID 2649653.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–2456. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198162 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008763 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9592125-5] Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.

[entrez-6] "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".

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