Article · Wikipedia archive · Last revised Aug 1, 2026

LP-211

LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor, with better brain penetration than older 5-HT7 agonists in the same series, and similar effects in animals.

Last revised
Aug 1, 2026
Read time
≈ 1 min
Length
132 w
Citations
2
Source
Wikipedia ↗
LP-211
Identifiers
  • N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC30H34N4O
Molar mass466.629 g·mol−1
3D model (JSmol)
  • N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4
  • InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) ☒N
  • Key:BQEDZLDNNBDKDS-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor, with better brain penetration than older 5-HT7 agonists in the same series, and similar effects in animals.12

See also

See also

References

References

  1. Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC 2910240. PMID 20600619.
  2. Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.