LILRB1

LILRB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0
Identifiers
Aliases	LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
External IDs	OMIM: 604811; HomoloGene: 88463; GeneCards: LILRB1; OMA:LILRB1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)1 Band 19q13.42 Start 54,617,158 bp1 End 54,638,022 bp1
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen monocyte appendix granulocyte blood lymph node bone marrow cell upper lobe of left lung right lung C1 segment n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity MHC class I receptor activity SH2 domain binding protein phosphatase 1 binding HLA-A specific inhibitory MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class I protein binding amyloid-beta binding protein binding MHC class Ib receptor activity MHC class Ib protein complex binding MHC class Ib protein binding Cellular component cytoplasm integral component of membrane membrane plasma membrane extracellular region external side of plasma membrane Biological process negative regulation of endocytosis dendritic cell differentiation negative regulation of mononuclear cell proliferation negative regulation of interferon-gamma production adaptive immune response Fc receptor mediated inhibitory signaling pathway negative regulation of osteoclast development immune system process response to virus receptor internalization negative regulation of cell cycle negative regulation of cytokine production involved in immune response negative regulation of serotonin secretion T cell proliferation involved in immune response negative regulation of alpha-beta T cell activation negative regulation of T cell mediated cytotoxicity positive regulation of cytolysis negative regulation of T cell proliferation positive regulation of gene expression defense response to virus negative regulation of calcium ion transport regulation of immune response positive regulation of apoptotic process negative regulation of natural killer cell mediated cytotoxicity negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell cellular response to lipopolysaccharide immune response-inhibiting cell surface receptor signaling pathway positive regulation of gamma-delta T cell activation involved in immune response negative regulation of dendritic cell apoptotic process negative regulation of dendritic cell differentiation signal transduction positive regulation of transcription by RNA polymerase II negative regulation of CD8-positive, alpha-beta T cell activation positive regulation of defense response to virus by host positive regulation of macrophage cytokine production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10859 n/a Ensembl ENSG00000104972 ENSG00000276452 ENSG00000277134 ENSG00000274669 ENSG00000277807 n/a n/a UniProt Q8NHL6 n/a RefSeq (mRNA) NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399 NM_006669 NM_001388355 NM_001388356 NM_001388357 NM_001388358 n/a RefSeq (protein) NP_001075106 NP_001075107 NP_001075108 NP_001265327 NP_001265328 NP_006660 n/a Location (UCSC) Chr 19: 54.62 – 54.64 Mb n/a PubMed search 2 n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.³⁴

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.⁵