LILRA1

LILRA1
Identifiers
Aliases	LILRA1, CD85I, LIR-6, LIR6, leukocyte immunoglobulin like receptor A1
External IDs	OMIM: 604810; HomoloGene: 134026; GeneCards: LILRA1; OMA:LILRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,602,381 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; appendix; ; testicle; ; bone marrow; ; bone marrow cell; ; right lung; ; upper lobe of left lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	antigen binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	defense response; cell surface receptor signaling pathway; adaptive immune response; regulation of immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	11024
	n/a
	ENSG00000275525; ENSG00000277398; ENSG00000104974; ENSG00000274935
	n/a
	O75019
	n/a
	NM_001278318; NM_001278319; NM_006863
	n/a
	NP_001265247; NP_001265248; NP_006854
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 is a protein that in humans is encoded by the LILRA1 gene.³

References

ENSG00000277398, ENSG00000104974, ENSG00000274935 GRCh38: Ensembl release 89: ENSG00000275525, ENSG00000277398, ENSG00000104974, ENSG00000274935 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1".

Further reading

Allen RL, Raine T, Haude A, Trowsdale J, Wilson MJ (November 2001). "Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures". Journal of Immunology. 167 (10): 5543–7. doi:10.4049/jimmunol.167.10.5543. PMID 11698424.
Tedla N, Lee CW, Borges L, Geczy CL, Arm JP (February 2008). "Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells". Journal of Leukocyte Biology. 83 (2): 334–43. doi:10.1189/jlb.0507314. PMID 17998301. S2CID 17379108.
Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J (April 2000). "Plasticity in the organization and sequences of human KIR/ILT gene families". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4778–83. Bibcode:2000PNAS...97.4778W. doi:10.1073/pnas.080588597. PMC 18309. PMID 10781084.
Brown D, Trowsdale J, Allen R (September 2004). "The LILR family: modulators of innate and adaptive immune pathways in health and disease". Tissue Antigens. 64 (3): 215–25. doi:10.1111/j.0001-2815.2004.00290.x. PMID 15304001.
Tedla N, An H, Borges L, Vollmer-Conna U, Bryant K, Geczy C, McNeil HP (April 2011). "Expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium: correlations to disease activity". Tissue Antigens. 77 (4): 305–16. doi:10.1111/j.1399-0039.2011.01633.x. PMID 21388353.
Pilsbury LE, Allen RL, Vordermeier M (2010). "Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection". Mediators of Inflammation. 2010 536478. doi:10.1155/2010/536478. PMC 2903975. PMID 20634939.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF (April 2011). Kanellopoulos J (ed.). "LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence". PLOS ONE. 6 (4) e19245. Bibcode:2011PLoSO...619245R. doi:10.1371/journal.pone.0019245. PMC 3084784. PMID 21559424.
Wang KS, Liu X, Aragam N, Mullersman JE, Jian X, Pan Y, Liu Y (February 2012). "Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence". Journal of Molecular Neuroscience. 46 (2): 265–71. doi:10.1007/s12031-011-9530-6. PMID 21547531. S2CID 6276103.

[refGRCh38Ensembl-1] ENSG00000277398, ENSG00000104974, ENSG00000274935 GRCh38: Ensembl release 89: ENSG00000275525, ENSG00000277398, ENSG00000104974, ENSG00000274935 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1".

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