LGR4

LGR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDs	OMIM: 606666; MGI: 1891468; HomoloGene: 10226; GeneCards: LGR4; OMA:LGR4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,472,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,844,602 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; hair follicle; ; gingival epithelium; ; rectum; ; decidua; ; mucosa of colon; ; mucosa of sigmoid colon; ; Epithelium of choroid plexus; ; metanephros; ; metanephric glomerulus;
	Top expressed in
	hand; ; otolith organ; ; epithelium of lens; ; utricle; ; renal corpuscle; ; ciliary body; ; Gonadal ridge; ; left colon; ; epithelium of stomach; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; transmembrane signaling receptor activity; G protein-coupled receptor activity; protein-hormone receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	hair follicle development; G protein-coupled receptor signaling pathway; cell differentiation; positive regulation of branching involved in ureteric bud morphogenesis; male genitalia development; metanephric nephron tubule morphogenesis; rhythmic process; metanephric glomerulus development; immune system process; epithelial cell proliferation; Wnt signaling pathway; tube morphogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; cell differentiation involved in metanephros development; intestinal stem cell homeostasis; epithelial cell proliferation involved in renal tubule morphogenesis; circadian rhythm; canonical Wnt signaling pathway involved in metanephric kidney development; digestive tract development; innate immune response; negative regulation of transcription, DNA-templated; signal transduction; positive regulation of canonical Wnt signaling pathway; bone remodeling; circadian regulation of gene expression; spermatogenesis; osteoblast differentiation; bone mineralization; negative regulation of toll-like receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; hormone-mediated signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55366
	107515
	ENSG00000205213
	ENSMUSG00000050199
	Q9BXB1
	A2ARI4
	NM_018490; NM_001346432
	NM_172671
	NP_001333361; NP_060960
	NP_766259
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.⁵⁶ LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

GRCh38: Ensembl release 89: ENSG00000205213 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000050199 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.
"Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

References

Further reading