L3MBTL2

L3MBTL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W0T, 3CEY, 3F70
Identifiers
Aliases	L3MBTL2, H-l(3)mbt-l, L3MBT, L3MBTL2 polycomb repressive complex 1 subunit, polycomb repressive complex 1 subunit, L3MBTL histone methyl-lysine binding protein 2
External IDs	OMIM: 611865; MGI: 2443584; HomoloGene: 12882; GeneCards: L3MBTL2; OMA:L3MBTL2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,231,271 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,572,516 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tibialis anterior muscle; ; parotid gland; ; nasal epithelium; ; skin of arm; ; mucosa of ileum; ; cerebellar vermis; ; external globus pallidus; ; gingival epithelium; ; right frontal lobe;
	Top expressed in
	spermatocyte; ; epiblast; ; otolith organ; ; hand; ; utricle; ; cumulus cell; ; superior cervical ganglion; ; tail of embryo; ; primary oocyte; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone binding; zinc ion binding; protein binding; metal ion binding; methylated histone binding;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of G0 to G1 transition; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	83746
	214669
	ENSG00000100395
	ENSMUSG00000022394
	Q969R5
	P59178
	NM_001003689; NM_031488
	NM_001289711; NM_001289712; NM_145993
	NP_113676
	NP_001276640; NP_001276641; NP_666105
	Wikidata
View/Edit Human	View/Edit Mouse

Lethal(3)malignant brain tumor-like 2 protein is a protein that in humans is encoded by the L3MBTL2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000100395 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022394 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wismar J (Oct 2001). "Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family". FEBS Letters. 507 (1): 119–21. doi:10.1016/S0014-5793(01)02959-3. PMID 11682070.
"Entrez Gene: L3MBTL2 l(3)mbt-like 2 (Drosophila)".

Further reading

Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (May 2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135. S2CID 34863978.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100395 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11682070-5] Wismar J (Oct 2001). "Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family". FEBS Letters. 507 (1): 119–21. doi:10.1016/S0014-5793(01)02959-3. PMID 11682070.

[entrez-6] "Entrez Gene: L3MBTL2 l(3)mbt-like 2 (Drosophila)".

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