Article · Wikipedia archive · Last revised Aug 5, 2026

Iodocholesterol

Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (131I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical. When the iodine atom is a radioactive isotope, it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma, and adrenal remnants following total adrenalectomy.

Last revised
Aug 5, 2026
Read time
≈ 1 min
Length
175 w
Citations
5
Source
Wikipedia ↗
Iodocholesterol
Clinical data
Other namesIodocholesterol; 19-Iodocholesterol; Iodocholesterol (131I); 19-Iodocholest-5-en-3β-ol
ATC code
Identifiers
  • (3S,8S,9S,10S,13R,14S,17R)-10-(iodomethyl)-13-methyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.048.618
Chemical and physical data
FormulaC27H45IO
Molar mass512.560 g·mol−1
3D model (JSmol)
  • CC(C)CCC[C@@H](C)[C@H]3CC[C@H]2[C@@H]4C\C=C1\C[C@@H](O)CC[C@]1(CI)[C@H]4CC[C@@]23C
  • InChI=1S/C27H45IO/c1-18(2)6-5-7-19(3)23-10-11-24-22-9-8-20-16-21(29)12-15-27(20,17-28)25(22)13-14-26(23,24)4/h8,18-19,21-25,29H,5-7,9-17H2,1-4H3/t19-,21+,22+,23-,24+,25+,26-,27-/m1/s1 checkY
  • Key:FIOAEFCJGZJUPW-FTLVODPJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (131I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical.12 When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism,3 pheochromocytoma, and adrenal remnants following total adrenalectomy.12

References

References

  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 692–. ISBN 978-1-4757-2085-3.
  2. Clark OH, American Cancer Society (2003). Endocrine Tumors. PMPH-USA. pp. 124–. ISBN 978-1-55009-134-2.
  3. Fischer M, Rosenbach EA, Glaser B, Stokar J (2023-02-24). "NP-59 Scintigraphy for Primary Aldosteronism Lateralization in a Patient With Polycystic Kidney Disease". AACE Clinical Case Reports. 9 (3): 97–98. doi:10.1016/j.aace.2023.02.006. PMC 10213608. PMID 37251975. S2CID 257212197.