INPP5B

INPP5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTC, 3N9V, 4CML, 5A7J, 5A7I
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	OMIM: 147264; MGI: 103257; HomoloGene: 69021; GeneCards: INPP5B; OMA:INPP5B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,947,057 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,695,304 bp
RNA expression pattern
	Top expressed in
	left ovary; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; right ovary; ; ascending aorta; ; granulocyte; ; left coronary artery; ; cerebellar hemisphere;
	Top expressed in
	right lung lobe; ; neural layer of retina; ; left lung; ; right kidney; ; proximal tubule; ; human kidney; ; granulocyte; ; lobe of cerebellum; ; cerebellar vermis; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding; hydrolase activity; GTPase activator activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol phosphate phosphatase activity;
Cellular component	integral component of membrane; cytosol; endosome; phagocytic vesicle membrane; Golgi apparatus; early endosome membrane; membrane; plasma membrane; cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; cytoplasm;
Biological process	flagellated sperm motility; in utero embryonic development; inositol phosphate metabolic process; regulation of protein processing; phosphatidylinositol dephosphorylation; spermatogenesis; regulation of small GTPase mediated signal transduction; signal transduction; positive regulation of GTPase activity; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3633
	16330
	ENSG00000204084
	ENSMUSG00000028894
	P32019
	Q8K337
	NM_001297434; NM_005540; NM_001350227; NM_001350228
	NM_008385
NP_001284363; NP_005531; NP_001337156; NP_001337157; NP_001352749;
	NP_001352750; NP_001352751; NP_001352752; NP_001352753; NP_001352754
	NP_032411
	Wikidata
View/Edit Human	View/Edit Mouse

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.⁵⁶

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.⁶

References

GRCh38: Ensembl release 89: ENSG00000204084 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028894 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. doi:10.1016/S0021-9258(18)54920-6. PMID 1718960.
"Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading

Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets". J. Biol. Chem. 264 (15): 8873–7. doi:10.1016/S0021-9258(18)81874-9. PMID 2542294.
Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370–7. doi:10.1074/jbc.270.16.9370. PMID 7721860.
Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34". Cytogenet. Cell Genet. 66 (3): 164–6. doi:10.1159/000133691. PMID 8125013.
Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase". Eur. J. Biochem. 234 (1): 216–24. doi:10.1111/j.1432-1033.1995.216_c.x. PMID 8529643.
Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens". Genomics. 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204084 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028894 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1718960-5] Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. doi:10.1016/S0021-9258(18)54920-6. PMID 1718960.

[entrez-6] "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

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