INHBC

INHBC
Identifiers
Aliases	INHBC, IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C
External IDs	OMIM: 601233; MGI: 105932; HomoloGene: 21142; GeneCards: INHBC; OMA:INHBC - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,452,062 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,206,300 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; tibialis anterior muscle; ; pancreatic ductal cell; ; mucosa of ileum; ; deltoid muscle; ; skin of thigh; ; cerebellum; ; cerebellar cortex; ; right hemisphere of cerebellum;
	Top expressed in
	liver; ; yolk sac; ; embryo; ; embryo; ; placenta; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; transforming growth factor beta receptor binding; hormone activity; cytokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of pathway-restricted SMAD protein phosphorylation; regulation of MAPK cascade; cell development; regulation of apoptotic process; SMAD protein signal transduction; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3626
	16325
	ENSG00000175189
	ENSMUSG00000025405
	P55103
	P55104
	NM_005538
	NM_010565
	NP_005529
	NP_034695
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.⁵⁶

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.⁶

References

GRCh38: Ensembl release 89: ENSG00000175189 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025405 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.
"Entrez Gene: INHBC inhibin, beta C".

Further reading

Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224.
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell. 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080. S2CID 36407277.
Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene". Genomics. 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799.
Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia". Prostate. 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386. S2CID 45515214.
Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jcem.85.12.7052. PMID 11134153.
Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901.
Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate". Endocrinology. 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042.
Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175189 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826378-5] H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.

[entrez-6] "Entrez Gene: INHBC inhibin, beta C".

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