Article · Wikipedia archive · Last revised Jul 27, 2026

Indium (111In) capromab pendetide

Indium (111In) capromab pendetide is used to image the extent of prostate cancer. Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).

Last revised
Jul 27, 2026
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Indium (111In) capromab pendetide
Monoclonal antibody
TypeWhole antibody
SourceMouse
TargetGlutamate carboxypeptidase II
Clinical data
Trade namesProstascint
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
ChEMBL
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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.1 Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.2 Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).1

Early trials with yttrium (90Y) capromab pendetide were also conducted.3

References

References

  1. Manyak MJ (February 2008). "Indium-111 capromab pendetide in the management of recurrent prostate cancer". Expert Review of Anticancer Therapy. 8 (2): 175–81. doi:10.1586/14737140.8.2.175. PMID 18279057. S2CID 30587577.
  2. WHO Drug Information
  3. Kahn D, Austin JC, Maguire RT, Miller SJ, Gerstbrein J, Williams RD (April 1999). "A phase II study of [90Y] yttrium-capromab pendetide in the treatment of men with prostate cancer recurrence following radical prostatectomy". Cancer Biotherapy & Radiopharmaceuticals. 14 (2): 99–111. doi:10.1089/cbr.1999.14.99. PMID 10850293.