IFNA5

IFNA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OQ3
Identifiers
Aliases	IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G, interferon alpha 5
External IDs	OMIM: 147565; MGI: 2667155; HomoloGene: 117697; GeneCards: IFNA5; OMA:IFNA5 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,305,313 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	88,562,696 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; Achilles tendon; ; sural nerve; ; stromal cell of endometrium; ; right coronary artery; ; right lung; ; gastric mucosa; ; right adrenal cortex; ; popliteal artery; ; tibial arteries;
	Top expressed in
	embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; type I interferon receptor binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	natural killer cell activation involved in immune response; B cell differentiation; defense response; B cell proliferation; blood coagulation; positive regulation of peptidyl-serine phosphorylation of STAT protein; humoral immune response; adaptive immune response; defense response to virus; type I interferon signaling pathway; response to exogenous dsRNA; T cell activation involved in immune response; innate immune response; cytokine-mediated signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3442
	230396
	ENSG00000147873
	ENSMUSG00000063376
	P01569
	Q80SU4
	NM_002169
	NM_177347
	NP_002160
	NP_796321
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000147873 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
"Entrez Gene: IFNA5 interferon, alpha 5".

Further reading

Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Chuntharapai A, Gibbs V, Lu J, et al. (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. doi:10.4049/jimmunol.163.2.766. PMID 10395669.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147873 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385305-5] Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

[entrez-6] "Entrez Gene: IFNA5 interferon, alpha 5".

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