HS3ST1

HS3ST1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZRH
Identifiers
Aliases	HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDs	OMIM: 603244; MGI: 1201606; HomoloGene: 3751; GeneCards: HS3ST1; OMA:HS3ST1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	11,429,564 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	39,912,818 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; left ovary; ; caput epididymis; ; oral cavity; ; buccal mucosa cell; ; right ovary; ; palpebral conjunctiva; ; epithelium of nasopharynx;
	Top expressed in
	cerebellar cortex; ; cumulus cell; ; lobe of cerebellum; ; olfactory bulb; ; dentate gyrus of hippocampal formation granule cell; ; gray matter layer of cerebellum; ; cerebellar vermis; ; primary visual cortex; ; ventricular zone; ; barrel cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	Golgi lumen; integral component of membrane; Golgi apparatus;
Biological process	glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9957
	15476
	ENSG00000002587
	ENSMUSG00000051022
	O14792
	O35310
	NM_005114
	NM_010474
	NP_005105
	NP_034604
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.⁵⁶

Function

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.⁶

Clinical significance

Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.⁷

References

GRCh38: Ensembl release 89: ENSG00000002587 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000051022 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
"Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".
Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. Bibcode:2018NatSR...818088W. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

External links

Overview of all the structural information available in the PDB for UniProt: O14792 (Human Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: O35310 (Mouse Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000002587 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9988767-5] Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.

[entrez-6] "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".

[7] Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. Bibcode:2018NatSR...818088W. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

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Function

Clinical significance

References

Further reading

External links