HMOX2

HMOX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q32, 2QPP, 2RGZ, 4WMH
Identifiers
Aliases	HMOX2, HO-2, heme oxygenase 2
External IDs	OMIM: 141251; MGI: 109373; HomoloGene: 1611; GeneCards: HMOX2; OMA:HMOX2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,510,347 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,584,606 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; prefrontal cortex; ; left ventricle; ; apex of heart; ; superior frontal gyrus; ; Brodmann area 9; ; right auricle of heart; ; nucleus accumbens; ; body of stomach;
	Top expressed in
	spermatid; ; seminiferous tubule; ; facial motor nucleus; ; anterior horn of spinal cord; ; dentate gyrus of hippocampal formation granule cell; ; supraoptic nucleus; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; metal ion binding; heme oxygenase (decyclizing) activity; heme binding;
Cellular component	intracellular membrane-bounded organelle; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; plasma membrane; specific granule membrane;
Biological process	response to hypoxia; cellular iron ion homeostasis; heme oxidation; response to oxidative stress; heme catabolic process; neutrophil degranulation; iron ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	3163
	15369
	ENSG00000277424; ENSG00000103415
	ENSMUSG00000004070
	P30519
	O70252
NM_001127204; NM_001127205; NM_001127206; NM_001286267; NM_001286268;
	NM_001286269; NM_001286270; NM_001286271; NM_002134
	NM_001136066; NM_010443; NM_001357050; NM_001378999
NP_001120676; NP_001120677; NP_001120678; NP_001273196; NP_001273197;
	NP_001273198; NP_001273199; NP_001273200; NP_002125
	NP_001129538; NP_034573; NP_001343979; NP_001365928
	Wikidata
View/Edit Human	View/Edit Mouse

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene.⁵⁶

Function

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.⁶

References

ENSG00000103415 GRCh38: Ensembl release 89: ENSG00000277424, ENSG00000103415 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000004070 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.
"Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

Further reading

Bianchetti CM, Yi L, Ragsdale SW, Phillips GN (2007). "Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2". J Biol Chem. 282 (52): 37624–31. doi:10.1074/jbc.M707396200. PMC 2896506. PMID 17965015.
Wang J, Zhuang H, Doré S (2006). "Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage". Neurobiol. Dis. 22 (3): 473–6. doi:10.1016/j.nbd.2005.12.009. PMID 16459095. S2CID 43195015.
Wang J, Doré S (2008). "Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage". Neuroscience. 155 (4): 1133–41. doi:10.1016/j.neuroscience.2008.07.004. PMC 4696610. PMID 18674596.
Barañano DE, Snyder SH (2001). "Neural roles for heme oxygenase: Contrasts to nitric oxide synthase". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 10996–1002. Bibcode:2001PNAS...9810996B. doi:10.1073/pnas.191351298. PMC 58673. PMID 11572959.
Doré S (2002). "Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease". Free Radic. Biol. Med. 32 (12): 1276–82. doi:10.1016/S0891-5849(02)00805-5. PMID 12057765.
Kemp PJ (2005). "Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction". Biochem. Biophys. Res. Commun. 338 (1): 648–52. doi:10.1016/j.bbrc.2005.08.110. PMID 16137652.
Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T (1995). "Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2". J. Biol. Chem. 270 (11): 6345–50. doi:10.1074/jbc.270.11.6345. PMID 7890772.
Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B (1994). "Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3". Genomics. 20 (3): 513–6. doi:10.1006/geno.1994.1213. PMID 8034330.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S (1996). "Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors". J. Neurochem. 67 (2): 482–9. doi:10.1046/j.1471-4159.1996.67020482.x. PMID 8764571. S2CID 12552519.
Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S (1997). "Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1". Cytogenet. Cell Genet. 77 (3–4): 180–1. doi:10.1159/000134570. PMID 9284910.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshiki N, Kubota T, Aso T (2000). "Expression and localization of heme oxygenase in human placental villi". Biochem. Biophys. Res. Commun. 276 (3): 1136–42. doi:10.1006/bbrc.2000.3551. PMID 11027601.
Hanselmann C, Mauch C, Werner S (2001). "Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?". Biochem. J. 353 (Pt 3): 459–66. doi:10.1042/0264-6021:3530459. PMC 1221590. PMID 11171041.
Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE (2003). "Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Heart Circ. Physiol. 284 (3): H853–8. doi:10.1152/ajpheart.00655.2002. PMID 12578814.
Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
Zenclussen AC, Lim E, Knoeller S, Knackstedt M, Hertwig K, Hagen E, Klapp BF, Arck PC (2004). "Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies". Am. J. Reprod. Immunol. 50 (1): 66–76. doi:10.1034/j.1600-0897.2003.00047.x. PMID 14506930. S2CID 35763984.
Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH (2003). "Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2". Neuron. 40 (1): 129–37. doi:10.1016/S0896-6273(03)00596-8. PMID 14527438. S2CID 11562548.
Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH (2004). "Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (6): R1453–60. doi:10.1152/ajpregu.00234.2003. PMID 14615405.

[refGRCh38Ensembl-1] ENSG00000103415 GRCh38: Ensembl release 89: ENSG00000277424, ENSG00000103415 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004070 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1575508-5] McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.

[entrez-6] "Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

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