HCST (gene)

HCST
Identifiers
Aliases	HCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer
External IDs	OMIM: 604089; MGI: 1344360; HomoloGene: 8024; GeneCards: HCST; OMA:HCST - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,904,377 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,119,279 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; bone marrow; ; blood; ; bone marrow cell; ; spleen; ; appendix; ; lymph node; ; thymus; ; trabecular bone;
	Top expressed in
	granulocyte; ; thymus; ; tibiofemoral joint; ; blood; ; spleen; ; mesenteric lymph nodes; ; embryo; ; embryo; ; duodenum; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; protein binding; phosphatidylinositol 3-kinase binding;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane;
Biological process	protein phosphorylation; regulation of immune response; positive regulation of phosphatidylinositol 3-kinase signaling;
	Sources:Amigo / QuickGO
Orthologs
	10870
	23900
	ENSG00000126264
	ENSMUSG00000064109
	Q9UBK5
	Q9QUJ0
	NM_014266; NM_001007469
	NM_011827
	NP_001007470; NP_055081
	NP_035957
	Wikidata
View/Edit Human	View/Edit Mouse

Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.⁵⁶

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.⁶

References

GRCh38: Ensembl release 89: ENSG00000126264 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000064109 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
"Entrez Gene: HCST hematopoietic cell signal transducer".

Further reading

Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells". J. Immunol. 175 (12): 7819–28. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors". Eur. J. Immunol. 34 (4): 961–71. doi:10.1002/eji.200324705. PMID 15048706.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nat. Immunol. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D". Immunogenetics. 53 (3): 243–9. doi:10.1007/s002510100321. PMID 11398969. S2CID 23708388.
Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells". J. Exp. Med. 192 (7): 1059–68. doi:10.1084/jem.192.7.1059. PMC 2193316. PMID 11015446.
Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4. doi:10.4049/jimmunol.163.9.4651. PMID 10528161.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126264 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064109 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10426994-5] Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Aug 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.

[entrez-6] "Entrez Gene: HCST hematopoietic cell signal transducer".

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