Article · Wikipedia archive · Last revised Jun 17, 2026

Haloprogin

Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections. It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Last revised
Jun 17, 2026
Read time
≈ 1 min
Length
193 w
Citations
3
Source
Wikipedia ↗
Haloprogin
Clinical data
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • US: Not available
Identifiers
  • 1,2,4-Trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.169
Chemical and physical data
FormulaC9H4Cl3IO
Molar mass361.38 g·mol−1
3D model (JSmol)
Melting point113.5 °C (236.3 °F)
Solubility in waterInsoluble mg/mL (20 °C)
  • Clc1cc(OCC#CI)c(Cl)cc1Cl
  • InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2 checkY
  • Key:CTETYYAZBPJBHE-UHFFFAOYSA-N checkY
  (verify)

Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections.1 It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over-the-counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.2

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.3

References

References

  1. Rudolph RI (December 1979). "Haloprogin as treatment for fungal infections". Clinical and Experimental Dermatology. 4 (4): 548. doi:10.1111/j.1365-2230.1979.tb01656.x. PMID 161212. S2CID 71471801.
  2. "Haloprogin". Drugs@FDA. Food and Drug Administration. Archived from the original on September 26, 2006. Retrieved 2007-02-17.
  3. "Haloprogin". DrugBank. University of Alberta. Nov 6, 2006. Retrieved 2007-02-17.