GPR63

GPR63
Identifiers
Aliases	GPR63, PSP24(beta), PSP24B, G protein-coupled receptor 63
External IDs	OMIM: 606915; MGI: 2135884; HomoloGene: 12759; GeneCards: GPR63; OMA:GPR63 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	96,837,477 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	25,009,233 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; ventricular zone; ; ganglionic eminence; ; popliteal artery; ; tibial arteries; ; prefrontal cortex; ; right coronary artery; ; rectum; ; left coronary artery;
	Top expressed in
	secondary oocyte; ; zygote; ; tail of embryo; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; ventricular zone; ; superior frontal gyrus; ; embryo; ; cerebellar cortex; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; molecular function;
Cellular component	integral component of membrane; receptor complex; membrane; nucleus; cytosol; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; biological process;
	Sources:Amigo / QuickGO
Orthologs
	81491
	81006
	ENSG00000112218
	ENSMUSG00000040372
	Q9BZJ6
	Q9EQQ3
	NM_001143957; NM_030784
	NM_030733; NM_001379626; NM_001379627
	NP_001137429; NP_110411
	NP_109658; NP_001366555; NP_001366556
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.⁵

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]⁵

References

GRCh38: Ensembl release 89: ENSG00000112218 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040372 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GPR63 G protein-coupled receptor 63".

Further reading

Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
Lee DK, George SR, Cheng R, et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res. Mol. Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Niedernberg A, Tunaru S, Blaukat A, et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112218 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040372 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR63 G protein-coupled receptor 63".

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