GPR174

GPR174
Identifiers
Aliases	GPR174, GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174
External IDs	OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	79,175,318 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	106,340,375 bp
RNA expression pattern
	Top expressed in
	thymus; ; mucosa of ileum; ; lymph node; ; granulocyte; ; appendix; ; epithelium of nasopharynx; ; epithelium of colon; ; spleen; ; superficial temporal artery; ; blood;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; blood; ; thymus; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; lumbar subsegment of spinal cord; ; granulocyte; ; white adipose tissue; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bioactive lipid receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; T cell homeostasis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84636
	213439
	ENSG00000147138
	ENSMUSG00000073008
	Q9BXC1
	Q3U507
	NM_032553
	NM_001033251; NM_001177781; NM_001177782; NM_001358747
	NP_115942
	NP_001028423; NP_001171252; NP_001171253; NP_001345676
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.⁵

Ligands

Agonists

GPR174 has been reported to bind to lysophosphatidylserine (LysoPS), and this appears to be the endogenous agonist.⁶⁷

Antagonists

N-acyl derivatives of LysoPS act as antagonists at GPR174.⁸

References

GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GPR174 G protein-coupled receptor 174".
Liu G LX (Dec 2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biology. 21 (12) e3002387. doi:10.1371/journal.pbio.3002387. PMC 10721165. PMID 38048360.
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, et al. (Sep 2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nature Communications. 14 (1) 5901. doi:10.1038/s41467-023-41654-3. PMC 10516915. PMID 37737235.
Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, et al. (July 2021). "Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine". Journal of Medicinal Chemistry. 64 (14): 10059–10101. doi:10.1021/acs.jmedchem.1c00347. PMID 34233115.

Ligands

References

Further reading