GON4L

GON4L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UG2
Identifiers
Aliases	GON4L, GON-4, GON4, YARP, gon-4 like
External IDs	OMIM: 610393; MGI: 1917579; HomoloGene: 13002; GeneCards: GON4L; OMA:GON4L - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,859,400 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,910,103 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; epithelium of colon; ; buccal mucosa cell; ; Achilles tendon; ; right uterine tube; ; apex of heart; ; anterior pituitary; ; gastric mucosa; ; right lobe of thyroid gland;
	Top expressed in
	saccule; ; zygote; ; otic vesicle; ; primary oocyte; ; otic placode; ; spermatocyte; ; secondary oocyte; ; neural layer of retina; ; tail of embryo; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nuclear body; nucleus;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; B cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	54856
	76022
	ENSG00000116580
	ENSMUSG00000054199
	Q3T8J9
	Q9DB00
NM_001037533; NM_001282856; NM_001282858; NM_001282860; NM_001282861;
	NM_032292; NM_025174
	NM_001242372; NM_027389
	NP_001269785; NP_001269787; NP_001269789; NP_001269790; NP_115668
	NP_001229301; NP_081665
	Wikidata
View/Edit Human	View/Edit Mouse

GON-4-like protein is a protein that in humans is encoded by the GON4L gene.⁵⁶ It is a nuclear protein containing two serine phosphosites and a lysine-glutamine cross-link ⁷ and is thought to be a transcription factor.⁸

References

GRCh38: Ensembl release 89: ENSG00000116580 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000054199 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Münstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (August 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
"Entrez Gene: GON4L gon-4-like (C. elegans)".
"Expasy listing: GON4L gon-4-like".
Online Mendelian Inheritance in Man (OMIM): GON4L gon-4-like - 610393

Further reading

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116580 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054199 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16545939-5] Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Münstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (August 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.

[entrez-6] "Entrez Gene: GON4L gon-4-like (C. elegans)".

[expasy-7] "Expasy listing: GON4L gon-4-like".

[OMIM-8] Online Mendelian Inheritance in Man (OMIM): GON4L gon-4-like - 610393

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