GLYCAM1

GLYCAM1
Identifiers
Aliases	GLYCAM1, glycosylation dependent cell adhesion molecule 1 (pseudogene)
External IDs	MGI: 95759; GeneCards: GLYCAM1; OMA:GLYCAM1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,610,462 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,473,508 bp
Orthologs
	644076
	14663
	ENSG00000257780
	ENSMUSG00000022491
	n; a
	Q02596
	n/a
	NM_001289587; NM_008134
	n/a
	NP_001276516; NP_032160
	Wikidata
View/Edit Human	View/Edit Mouse

Glycosylation-dependent cell adhesion molecule-1 is a protein that is encoded by the GLYCAM1 gene. In humans, GLYCAM1 is a pseudogene while in many other mammals including mouse, it is a protein coding gene.

GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.⁵⁶ GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.⁷

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.⁵

References

GRCh38: Ensembl release 89: ENSG00000257780 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022491 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Imhof BA, Dunon D (1995). Leukocyte Migration and Adhesion. Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN 978-0-12-022458-6. PMID 7537936.
Brustein M, Kraal G, Mebius RE, Watson SR (November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC 2119429. PMID 1383387.
Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.

External links

GlyCAM-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000257780 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022491 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Imhof_1995-5] Imhof BA, Dunon D (1995). Leukocyte Migration and Adhesion. Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN 978-0-12-022458-6. PMID 7537936.

[6] Brustein M, Kraal G, Mebius RE, Watson SR (November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC 2119429. PMID 1383387.

[7] Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.

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