GL64

GL64
Identifiers
	IUPAC name 3-(4-chlorophenyl)-2-[3-[(2,4-dichlorophenyl)methoxy]phenyl]-1,2-dihydroquinazolin-4-one;
CAS Number	488801-10-1;
PubChem CID	3693275;
ChemSpider	2925337;
Chemical and physical data
Formula	C27H19Cl3N2O2
Molar mass	509.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C2C(=C1)C(=O)N(C(N2)C3=CC(=CC=C3)OCC4=C(C=C(C=C4)Cl)Cl)C5=CC=C(C=C5)Cl;
	InChI InChI=1S/C27H19Cl3N2O2/c28-19-10-12-21(13-11-19)32-26(31-25-7-2-1-6-23(25)27(32)33)17-4-3-5-22(14-17)34-16-18-8-9-20(29)15-24(18)30/h1-15,26,31H,16H2; Key:OPKSEEXRWAXFIK-UHFFFAOYSA-N;

GL64 is a chemical compound which acts as an agonist at the androgen receptor GPR133. It increases bone density by inhibiting osteoclastogenesis, and shows beneficial effects in an animal model of osteoporosis.¹

References

He L, Zhang Q, You Y, Sun P, Xu Z, Li R, et al. (July 2025). "Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis". Science Advances. 11 (28) eads3829. doi:10.1126/sciadv.ads3829. PMC 12248284. PMID 40644539.

[1] He L, Zhang Q, You Y, Sun P, Xu Z, Li R, et al. (July 2025). "Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis". Science Advances. 11 (28) eads3829. doi:10.1126/sciadv.ads3829. PMC 12248284. PMID 40644539.

1

Identifiers

IUPAC name 3-(4-chlorophenyl)-2-[3-[(2,4-dichlorophenyl)methoxy]phenyl]-1,2-dihydroquinazolin-4-one
CAS Number	488801-10-1
PubChem CID	3693275
ChemSpider	2925337
Chemical and physical data
Formula	C₂₇H₁₉Cl₃N₂O₂
Molar mass	509.81 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C2C(=C1)C(=O)N(C(N2)C3=CC(=CC=C3)OCC4=C(C=C(C=C4)Cl)Cl)C5=CC=C(C=C5)Cl
InChI InChI=1S/C27H19Cl3N2O2/c28-19-10-12-21(13-11-19)32-26(31-25-7-2-1-6-23(25)27(32)33)17-4-3-5-22(14-17)34-16-18-8-9-20(29)15-24(18)30/h1-15,26,31H,16H2 Key:OPKSEEXRWAXFIK-UHFFFAOYSA-N

See also

References