GFI1

GFI1
Identifiers
Aliases	GFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor
External IDs	OMIM: 600871; MGI: 103170; HomoloGene: 3854; GeneCards: GFI1; OMA:GFI1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)1 Band 1p22.1 Start 92,473,043 bp1 End 92,486,925 bp1
Gene location (Mouse) Chr. Chromosome 5 (mouse)2 Band 5 F|5 52.23 cM Start 107,864,523 bp2 End 107,873,902 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte bone marrow bone marrow cell trabecular bone body of pancreas testicle thymus blood lymph node spleen Top expressed in utricle vestibular sensory epithelium thymus saccule granulocyte spermatocyte bone marrow tongue mesenteric lymph nodes embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nuclear body nuclear matrix transcription repressor complex nucleus nucleoplasm Biological process positive regulation of interleukin-6-mediated signaling pathway negative regulation of neuron projection development regulation of transcription, DNA-templated regulation of toll-like receptor signaling pathway regulation of histone H3-K4 methylation negative regulation of transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated negative regulation of vitamin D biosynthetic process negative regulation of calcidiol 1-monooxygenase activity viral process negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity cellular response to lipopolysaccharide hemopoiesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2672 14581 Ensembl ENSG00000162676 ENSMUSG00000029275 UniProt Q99684 P70338 RefSeq (mRNA) NM_001127215 NM_001127216 NM_005263 NM_001267621 NM_010278 RefSeq (protein) NP_001120687 NP_001120688 NP_005254 NP_001254550 NP_034408 Location (UCSC) Chr 1: 92.47 – 92.49 Mb Chr 5: 107.86 – 107.87 Mb PubMed search 3 4
Wikidata
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Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene.⁵ It is important normal hematopoiesis.⁶

Gfi1 (growth factor independence 1) is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Gfi1 upregulates the expression of the nuclear protein Hemgn, which contributes to its anti-apoptotic activity. This upregulation is mediated through a specific 16-bp promoter region and is dependent on Gfi1’s interaction with the histone demethylase LSD1.⁷ Gfi1 represses PU.1 transcription factor, and this repression precedes and correlates with the upregulation of Hemgn. The upregulation of Hemgn, in turn, contributes to the anti-apoptotic function of Gfi1, acting in a p53-independent manner.⁷⁸

Gfi1 promotes cell survival by upregulating Hemgn through the repression of PU.1 thereby inhibiting apoptosis.⁷ Gfi1 inhibits apoptosis induced by DNA damage, growth factor withdrawal, inhibitory cytokine TGF-β and MYC activation ⁸

Gfi1 is also expressed in the inner ear, and in the epithelium lining the stomach, intestines, and lung airways, where it is important for cellular differentiation.⁹¹⁰

GFI1 has been shown to interact with PIAS3¹¹ and RUNX1T1.¹²