Article · Wikipedia archive · Last revised Jun 18, 2026

Gabamide

Gabamide, or GABAmide, also known as γ-aminobutyramide (GABAD), is a GABA receptor agonist and GABA analogue, or more specifically the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite of the anticonvulsant drug progabide. Unlike progabide, but similarly to GABA, gabamide is unable to cross the blood–brain barrier and hence is peripherally selective. However, gabamide and GABA are formed in the brain from progabide following its entry into this part of the body.

Last revised
Jun 18, 2026
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Gabamide
Clinical data
Other namesGABAmide; GABAMIDE; GABA amide; 4-Aminobutanamide; 4-ABAD; 4-Aminobutyramide; gamma-Aminobutyramide; γ-Aminobutyramide; GABAD; gamma-Aminobutyric acid amide; γ-Aminobutyric acid amide
Drug classGABA receptor agonist
ATC code
  • None
Identifiers
  • 4-aminobutanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.019.852
Chemical and physical data
FormulaC4H10N2O
Molar mass102.137 g·mol−1
3D model (JSmol)
  • C(CC(=O)N)CN
  • InChI=1S/C4H10N2O/c5-3-1-2-4(6)7/h1-3,5H2,(H2,6,7)
  • Key:WCVPFJVXEXJFLB-UHFFFAOYSA-N

Gabamide, or GABAmide, also known as γ-aminobutyramide (GABAD), is a GABA receptor agonist and GABA analogue, or more specifically the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).12 Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite of the anticonvulsant drug progabide (Gabrene; SL-76.002).12 Unlike progabide, but similarly to GABA, gabamide is unable to cross the blood–brain barrier and hence is peripherally selective.2 However, gabamide and GABA are formed in the brain from progabide following its entry into this part of the body.2

See also

See also

References

References

  1. Bartholini G (1981). "Present Knowledge of GABA Receptor Agonists". Medicinal Chemistry Advances. Elsevier. pp. 345–353. doi:10.1016/b978-0-08-025297-1.50032-5. ISBN 978-0-08-025297-1. Retrieved 6 October 2025.
  2. Bergmann KJ (1985). "Progabide: a new GABA-mimetic agent in clinical use". Clinical Neuropharmacology. 8 (1): 13–26. doi:10.1097/00002826-198503000-00002. PMID 2983890. Progabide, a new synthetic compound defined as the Schiff base of gamma-aminobutyramide and a substituted benzophenone, has been developed. Well absorbed, and relatively free of toxicity, it is both a direct GABA receptor agonist as well as an exogenous source of GABA. [...]