FOXI3

FOXI3
Identifiers
Aliases	FOXI3, forkhead box I3
External IDs	OMIM: 612351; MGI: 3511278; HomoloGene: 52949; GeneCards: FOXI3; OMA:FOXI3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	88,452,693 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	70,938,050 bp
RNA expression pattern
	Top expressed in
	gonad; ; placenta; ; testicle; ; ganglionic eminence; ; anterior pituitary; ; skin of abdomen; ; skin of leg; ; renal cortex;
	Top expressed in
	pharyngeal pouch; ; cervical loop; ; stellate reticulum; ; hair follicle; ; salivary gland; ; epiblast; ; inner enamel epithelium; ; surface ectoderm; ; embryo; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	344167
	232077
	ENSG00000214336
	ENSMUSG00000055874
	A8MTJ6
	n/a
	NM_001135649
	NM_001101464
	NP_001129121
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Forkead box I3 (FOXI3) is a protein that in humans is encoded by the FOXI3 gene. FOXI3 is a forkhead box transcription factor that is expressed in the development of hair and teeth. One of its mutations is a dominant allele responsible for the heterozygous Hh hairless trait in dogs. It was identified in 2008.⁵

References

GRCh38: Ensembl release 89: ENSG00000214336 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055874 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science. 321 (5895): 1462. Bibcode:2008Sci...321.1462D. doi:10.1126/science.1162525. PMID 18787161. S2CID 206514824.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000214336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055874 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science. 321 (5895): 1462. Bibcode:2008Sci...321.1462D. doi:10.1126/science.1162525. PMID 18787161. S2CID 206514824.

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See also

References