Article · Wikipedia archive · Last revised Jun 29, 2026

Fourphit

Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist. It blocks the binding of methylphenidate to the DAT in vitro, though apparently not in vivo. In any case, the drug reduces the stimulant-like effects of cocaine in animals, whilst producing mostly negligible behavioral effects itself. Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).

Last revised
Jun 29, 2026
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≈ 1 min
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Fourphit
Clinical data
Other names4-Isothiocyanato-PCP
Drug classIrreversible dopamine transporter blocker; Reversible NMDA receptor antagonist; Psychostimulant antagonist
Identifiers
  • 4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H24N2S
Molar mass300.46 g·mol−1
3D model (JSmol)
  • C1CCC(CC1)(C2=CC=CC=C2)N3CCC(CC3)N=C=S
  • InChI=1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
  • Key:QAHYIAVTWZVTMY-UHFFFAOYSA-N

Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist.12 It blocks the binding of methylphenidate to the DAT in vitro,1 though apparently not in vivo.2 In any case, the drug reduces the stimulant-like effects of cocaine in animals,2 whilst producing mostly negligible behavioral effects itself.2 Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).1

See also

See also

References

References

  1. Schweri MM, Thurkauf A, Mattson MV, Rice KC (June 1992). "Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter". J Pharmacol Exp Ther. 261 (3): 936–942. doi:10.1016/S0022-3565(25)11167-1. PMID 1602399.
  2. Schweri MM, de Costa BR, Rice KC (July 1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacol Biochem Behav. 60 (3): 615–623. doi:10.1016/s0091-3057(98)00040-9. PMID 9678644.