FOLR2

FOLR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KMY, 4KMZ, 4KN0, 4KN1, 4KN2
Identifiers
Aliases	FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
External IDs	OMIM: 136425; MGI: 95569; HomoloGene: 627; GeneCards: FOLR2; OMA:FOLR2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,221,950 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,506,401 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; right coronary artery; ; synovial joint; ; lymph node; ; synovial membrane; ; gonad; ; pericardium; ; decidua; ; testicle; ; rectum;
	Top expressed in
	stroma of bone marrow; ; lip; ; ankle joint; ; white adipose tissue; ; esophagus; ; muscle of thigh; ; ankle; ; mammary gland; ; subcutaneous adipose tissue; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methotrexate binding; folic acid binding; folic acid receptor activity; signaling receptor activity;
Cellular component	cell surface; anchored component of membrane; anchored component of external side of plasma membrane; membrane; extracellular region; plasma membrane;
Biological process	inflammatory response; receptor-mediated endocytosis; positive regulation of cell population proliferation; monocyte chemotaxis; cellular response to folic acid; folic acid metabolic process; folic acid transport; folate import across plasma membrane; cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; sperm-egg recognition;
	Sources:Amigo / QuickGO
Orthologs
	2350
	14276
	ENSG00000165457
	ENSMUSG00000032725
	P14207
	Q05685
	NM_000803; NM_001113534; NM_001113535; NM_001113536
	NM_008035; NM_001303231; NM_001303239
	NP_000794; NP_001107006; NP_001107007; NP_001107008
	NP_001290160; NP_001290168; NP_032061
	Wikidata
View/Edit Human	View/Edit Mouse

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.⁵⁶⁷

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence identity with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.⁷

References

GRCh38: Ensembl release 89: ENSG00000165457 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032725 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kawasaki K, Fearnhead RW (Sep 1975). "On the relationship between tetracycline and the incremental lines in dentine". J Anat. 119 (Pt 1): 49–59. PMC 1231614. PMID 1133088.
van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet. 69 (3–4): 127–58. doi:10.1159/000133953. PMID 7698003.
"Entrez Gene: FOLR2 folate receptor 2 (fetal)".

Further reading

Henderson GB (1990). "Folate-binding proteins". Annu. Rev. Nutr. 10: 319–35. doi:10.1146/annurev.nu.10.070190.001535. PMID 2166548.
Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13". Genomics. 14 (2): 423–30. doi:10.1016/S0888-7543(05)80236-8. PMID 1330883.
Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul. 29: 13–26. doi:10.1016/0065-2571(89)90091-5. PMID 2561247.
Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA". Biochemistry. 28 (20): 8249–54. doi:10.1021/bi00446a042. PMID 2605182.
Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID 7578066.
Sadasivan E, Cedeno MM, Rothenberg SP (1994). "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein". J. Biol. Chem. 269 (7): 4725–35. doi:10.1016/S0021-9258(17)37605-6. PMID 8106441.
Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity". Biochemistry. 33 (5): 1209–15. doi:10.1021/bi00171a021. PMID 8110752.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Page ST, Owen WC, Price K, Elwood PC (1993). "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene". J. Mol. Biol. 229 (4): 1175–83. doi:10.1006/jmbi.1993.1116. PMID 8445646.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wang J, Shen F, Yan W, et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion". Biochemistry. 36 (47): 14583–92. doi:10.1021/bi970845w. PMID 9398177.
Nakashima-Matsushita N, Homma T, Yu S, et al. (1999). "Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis". Arthritis Rheum. 42 (8): 1609–16. doi:10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L. PMID 10446858.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hao H, Qi H, Ratnam M (2003). "Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites". Blood. 101 (11): 4551–60. doi:10.1182/blood-2002-10-3174. PMID 12543860.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032725 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1133088-5] Kawasaki K, Fearnhead RW (Sep 1975). "On the relationship between tetracycline and the incremental lines in dentine". J Anat. 119 (Pt 1): 49–59. PMC 1231614. PMID 1133088.

[pmid7698003-6] van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet. 69 (3–4): 127–58. doi:10.1159/000133953. PMID 7698003.

[entrez-7] "Entrez Gene: FOLR2 folate receptor 2 (fetal)".

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