FEM1A

FEM1A
Identifiers
Aliases	FEM1A, EPRAP, fem-1 homolog A
External IDs	OMIM: 613538; MGI: 1335089; HomoloGene: 7713; GeneCards: FEM1A; OMA:FEM1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,801,273 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,570,610 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; tibialis anterior muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; myocardium of left ventricle; ; deltoid muscle; ; body of tongue; ; cardiac muscle tissue of right atrium;
	Top expressed in
	extensor digitorum longus muscle; ; plantaris muscle; ; muscle of thigh; ; cardiac muscle tissue of left ventricle; ; gastrocnemius muscle; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle; ; temporal muscle; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	EP4 subtype prostaglandin E2 receptor binding; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	negative regulation of inflammatory response; protein ubiquitination; regulation of ubiquitin-protein transferase activity; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	55527
	14154
	ENSG00000141965
	ENSMUSG00000043683
	Q9BSK4
	Q9Z2G1
	NM_018708
	NM_010192
	NP_061178
	NP_034322
	Wikidata
View/Edit Human	View/Edit Mouse

Fem-1 homolog A is a protein that in humans is encoded by the FEM1A gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000141965 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043683 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Fem-1 homolog A". Retrieved 2018-09-21.

Further reading

Ventura-Holman T, Hahn H, Subauste JS, Maher JF (2005). "The Fem1a gene is downregulated in Rhabdomyosarcoma". Tumour Biol. 26 (6): 294–9. doi:10.1159/000089261. PMID 16254458. S2CID 2202410.
Maher JF, Hines RS, Futterweit W, Crawford S, Lu D, Shen P, Oefner P, Kazi M, Wilson JG, Subauste JS, Cowan BD (December 2005). "FEM1A is a candidate gene for polycystic ovary syndrome". Gynecol. Endocrinol. 21 (6): 330–5. doi:10.1080/09513590500431458. PMID 16390781. S2CID 24793473.
Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P (April 2008). "Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation". J. Biol. Chem. 283 (15): 9692–703. doi:10.1074/jbc.M709663200. PMC 2442287. PMID 18270204.
Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC 2583941. PMID 18757445.
Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC 2583941. PMID 18757445.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344. PMID 19948975.
Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS, Dunaif A, Strauss JF, Spielman RS (May 2010). "Family-based analysis of candidate genes for polycystic ovary syndrome". J. Clin. Endocrinol. Metab. 95 (5): 2306–15. doi:10.1210/jc.2009-2703. PMC 2869537. PMID 20200332.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141965 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043683 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Fem-1 homolog A". Retrieved 2018-09-21.

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