Article · Wikipedia archive · Last revised Aug 2, 2026

Fedrilate

Fedrilate is a centrally acting cough suppressant. It was patented as a mucolytic by UCB in 1971, but was never brought to market in the US. In the Netherlands, it has been marketed as Tussefan and in combination with guaifenesin as Tussefan expectorans.

Last revised
Aug 2, 2026
Read time
≈ 1 min
Length
111 w
Citations
2
Source
Wikipedia ↗
Fedrilate
Clinical data
Trade namesTussefan
ATC code
Identifiers
  • 4-morpholin-4-ylbutan-2-yl 4-phenyloxane-4-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.390
Chemical and physical data
FormulaC20H29NO4
Molar mass347.455 g·mol−1
3D model (JSmol)
  • O=C(OC(CCN1CCOCC1)C)C3(c2ccccc2)CCOCC3
  • InChI=1S/C20H29NO4/c1-17(7-10-21-11-15-24-16-12-21)25-19(22)20(8-13-23-14-9-20)18-5-3-2-4-6-18/h2-6,17H,7-16H2,1H3 checkY
  • Key:RDEOYUSTRWNWLX-UHFFFAOYSA-N checkY
  (verify)

Fedrilate is a centrally acting cough suppressant. It was patented as a mucolytic by UCB in 1971, but was never brought to market in the US.1 In the Netherlands, it has been marketed as Tussefan and in combination with guaifenesin as Tussefan expectorans.2

References

References

  1. US patent 3567835, Henri Morren, "Mucolytic salts, compositions and process for treating mucus", issued March 2, 1971 
  2. Kok J, Oosterveld WJ, Sibilo SR (1979). Pharmacotherapeutisch Vademecum (in Dutch). Bussum: Romen. ISBN 90-228-8006-0.