FCHSD2

FCHSD2
Identifiers
Aliases	FCHSD2, NWK, SH3MD3, FCH and double SH3 domains 2, NWK1
External IDs	OMIM: 617556; MGI: 2448475; HomoloGene: 8887; GeneCards: FCHSD2; OMA:FCHSD2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DL5, 2DL7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,142,318 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,933,612 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; lymph node; ; right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; ventricular zone; ; right lung; ; left coronary artery; ; appendix;
	Top expressed in
	zygote; ; mesenteric lymph nodes; ; secondary oocyte; ; primary oocyte; ; habenula; ; paraventricular nucleus of hypothalamus; ; otolith organ; ; trigeminal ganglion; ; utricle; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; lipid binding;
Cellular component	neuromuscular junction; recycling endosome; plasma membrane; clathrin-coated pit; stereocilium shaft; cytoplasm; membrane; cell junction; stereocilium; cell projection;
Biological process	neuromuscular synaptic transmission; regulation of actin filament polymerization; positive regulation of actin filament polymerization; clathrin-dependent endocytosis; positive regulation of Arp2/3 complex-mediated actin nucleation; endocytosis; protein transport;
	Sources:Amigo / QuickGO
Orthologs
	9873
	207278
	ENSG00000137478
	ENSMUSG00000030691
	O94868
	Q3USJ8
	NM_014824
	NM_001146010; NM_199012
	NP_055639
	NP_001139482; NP_950177
	Wikidata
View/Edit Human	View/Edit Mouse

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.⁵⁶⁷

Interactions

FCHSD2 has been shown to interact with MAGI1⁸ and C2orf73.⁹

References

GRCh38: Ensembl release 89: ENSG00000137478 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030691 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Katoh M, Katoh M (May 2004). "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico". International Journal of Molecular Medicine. 13 (5): 749–54. doi:10.3892/ijmm.13.5.749. PMID 15067381.
"Entrez Gene: FCHSD2 FCH and double SH3 domains 2".
Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983. S2CID 6289557.
Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ (August 2008). "Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach". Proteomics. 8 (15): 3071–81. doi:10.1002/pmic.200701157. PMID 18654987. S2CID 25344443.

Further reading

Petitjean C, Scheydeker JL, Suinat JL, Rendoing J (1976). "[Pulmonary edema in hangings]". De l'Anesthésiologie Française. 16. 16 Spec No 2-3: 57–65. PMID 9873.
Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983. S2CID 6289557.
Coyle IP, Koh YH, Lee WC, Slind J, Fergestad T, Littleton JT, Ganetzky B (February 2004). "Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila". Neuron. 41 (4): 521–34. doi:10.1016/S0896-6273(04)00016-9. PMID 14980202. S2CID 797812.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (March 2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137478 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030691 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid15067381-6] Katoh M, Katoh M (May 2004). "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico". International Journal of Molecular Medicine. 13 (5): 749–54. doi:10.3892/ijmm.13.5.749. PMID 15067381.

[entrez-7] "Entrez Gene: FCHSD2 FCH and double SH3 domains 2".

[pmid14627983-8] Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983. S2CID 6289557.

[9] Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ (August 2008). "Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach". Proteomics. 8 (15): 3071–81. doi:10.1002/pmic.200701157. PMID 18654987. S2CID 25344443.

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