FCHO1

FCHO1
Identifiers
Aliases	FCHO1, FCH domain only 1, FCH and mu domain containing endocytic adaptor 1
External IDs	OMIM: 613437; MGI: 1921265; HomoloGene: 22869; GeneCards: FCHO1; OMA:FCHO1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,788,568 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,178,360 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; C1 segment; ; oocyte; ; right frontal lobe; ; blood; ; right hemisphere of cerebellum; ; lymph node; ; monocyte; ; putamen; ; prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; thymus; ; perirhinal cortex; ; entorhinal cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; primary motor cortex; ; olfactory tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	AP-2 adaptor complex binding; protein binding; phospholipid binding; microtubule binding; cytoskeletal protein binding; tubulin binding;
Cellular component	plasma membrane; clathrin-coated pit; membrane; clathrin-coated vesicle; nucleoplasm; cytosol; cytoplasm; cytoskeleton; AP-2 adaptor complex;
Biological process	clathrin-dependent endocytosis; endocytosis; clathrin coat assembly; membrane organization; plasma membrane tubulation;
	Sources:Amigo / QuickGO
Orthologs
	23149
	74015
	ENSG00000130475
	ENSMUSG00000070000
	O14526
	Q8K285
	NM_001161357; NM_001161358; NM_001161359; NM_015122
	NM_028715
	NP_001154829; NP_001154830; NP_001154831; NP_055937
	NP_082991
	Wikidata
View/Edit Human	View/Edit Mouse

FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000130475 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000070000 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: FCH domain only 1". Retrieved 2017-05-13.

Further reading

Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K (2007). "Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8. doi:10.1271/bbb.60720. PMID 17617719. S2CID 21432830.
Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010). "FCHo proteins are nucleators of clathrin-mediated endocytosis". Science. 328 (5983): 1281–4. Bibcode:2010Sci...328.1281H. doi:10.1126/science.1188462. PMC 2883440. PMID 20448150.
Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM (2012). "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning". Nat. Cell Biol. 14 (5): 488–501. doi:10.1038/ncb2473. PMC 3354769. PMID 22484487.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130475 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070000 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FCH domain only 1". Retrieved 2017-05-13.

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