Article · Wikipedia archive · Last revised Jul 16, 2026

Famprofazone

Famprofazone, sold under the brand names Gewodin and Gewolen, is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan. It has analgesic, anti-inflammatory, and antipyretic effects. Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it. As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.

Last revised
Jul 16, 2026
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Citations
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Famprofazone
Clinical data
Trade namesGewodin, Gewolen
Routes of
administration		Oral
Drug classNonsteroidal anti-inflammatory agent (NSAID); Analgesic; Antipyretic; Stimulant
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
MetabolitesMethamphetamine
Identifiers
  • 1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3H-pyrazol-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.153
Chemical and physical data
FormulaC24H31N3O
Molar mass377.532 g·mol−1
3D model (JSmol)
  • O=C2\C(=C(/N(N2c1ccccc1)C)CN(C(C)Cc3ccccc3)C)C(C)C
  • InChI=1S/C24H31N3O/c1-18(2)23-22(17-25(4)19(3)16-20-12-8-6-9-13-20)26(5)27(24(23)28)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3
  • Key:GNUXVOXXWGNPIV-UHFFFAOYSA-N

Famprofazone, sold under the brand names Gewodin and Gewolen, is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.123 It has analgesic, anti-inflammatory, and antipyretic effects.12 Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it.45 As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.3

See also

See also

References

References

  1. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
  2. Hall JA, Morton I (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342. ISBN 0-7514-0499-3.
  3. Chan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse". Journal of Analytical Toxicology. 34 (6): 347–353. doi:10.1093/jat/34.6.347. PMID 20663288.
  4. Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22 (3): 377–384. doi:10.3109/00498259209046649. PMID 1496827. The results provide further evidence that methamphetamine is a bona fide human metabolite of famprofazone and suggest that at least 20% dose may be broken down via the pathways leading to the formation of methamphetamine.
  5. Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998). "Identification of new urinary metabolites of famprofazone in humans". Journal of Analytical Toxicology. 22 (1): 55–60. doi:10.1093/jat/22.1.55. PMID 9491970. The major metabolite, representing approximately 15% of the dose, was methamphetamine.
External links