Extended synaptotagmin-2

ESYT2
Identifiers
Aliases	ESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2
External IDs	OMIM: 616691; MGI: 1261845; HomoloGene: 32699; GeneCards: ESYT2; OMA:ESYT2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DMG, 4NPJ, 4NPK, 4P42
Gene location (Human)
Chr.	Chromosome 7 (human)
End	158,830,253 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	116,354,670 bp
RNA expression pattern
	Top expressed in
	synovial membrane; ; Achilles tendon; ; saphenous vein; ; synovial joint; ; endothelial cell; ; urethra; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; skin of arm; ; skin of hip;
	Top expressed in
	interventricular septum; ; decidua; ; uterus; ; umbilical cord; ; ascending aorta; ; superior cervical ganglion; ; secondary oocyte; ; cervix; ; granulocyte; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; calcium ion binding; protein binding; metal ion binding; phosphatidylinositol binding; phosphatidylethanolamine binding; phosphatidylcholine binding; identical protein binding; lipid binding; cadherin binding;
Cellular component	intrinsic component of endoplasmic reticulum membrane; organelle membrane contact site; integral component of membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; integral component of plasma membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site;
Biological process	lipid transport; endocytosis; glycosphingolipid metabolic process; transport; endoplasmic reticulum-plasma membrane tethering;
	Sources:Amigo / QuickGO
Orthologs
	57488
	52635
	ENSG00000117868
	ENSMUSG00000021171
	A0FGR8
	Q3TZZ7
	NM_020728
	NM_028731
	NP_065779; NP_001354702
	NP_083007
	Wikidata
View/Edit Human	View/Edit Mouse

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021171 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
"Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021171 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17672888-5] Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.

[entrez-6] "Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

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