Extended synaptotagmin-1

ESYT1
Identifiers
Aliases	ESYT1, FAM62A, MBC2, extended synaptotagmin protein 1, extended synaptotagmin 1
External IDs	OMIM: 616670; MGI: 1344426; HomoloGene: 40794; GeneCards: ESYT1; OMA:ESYT1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,144,674 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,361,740 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; granulocyte; ; right uterine tube; ; gastric mucosa; ; body of uterus; ; subcutaneous adipose tissue; ; right coronary artery; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries;
	Top expressed in
	granulocyte; ; lip; ; esophagus; ; muscle of thigh; ; zygote; ; ascending aorta; ; thymus; ; pharynx; ; tail of embryo; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; lipid binding; identical protein binding; calcium ion binding; calcium-dependent phospholipid binding; phosphatidylethanolamine binding; phosphatidylcholine binding; phosphatidylinositol binding;
Cellular component	organelle membrane contact site; integral component of membrane; integral component of endoplasmic reticulum membrane; plasma membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; intrinsic component of endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane;
Biological process	lipid transport; glycosphingolipid metabolic process; transport; endoplasmic reticulum-plasma membrane tethering;
	Sources:Amigo / QuickGO
Orthologs
	23344
	23943
	ENSG00000139641
	ENSMUSG00000025366
	Q9BSJ8
	Q3U7R1
	NM_015292; NM_001184796
	NM_011843
	NP_001171725; NP_056107
	NP_035973
	Wikidata
View/Edit Human	View/Edit Mouse

Extended synaptotagmin-1 is a protein in humans that is encoded by the ESYT1 gene.⁵⁶⁷⁸

References

GRCh38: Ensembl release 89: ENSG00000139641 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025366 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Morris NJ, Ross SA, Neveu JM, Lane WS, Lienhard GE (Jul 1999). "Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains". Biochim Biophys Acta. 1431 (2): 525–30. doi:10.1016/S0167-4838(99)00068-0. PMID 10350628.
Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
"Entrez Gene: FAM62A family with sequence similarity 62 (C2 domain containing), member A".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139641 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025366 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid10350628-6] Morris NJ, Ross SA, Neveu JM, Lane WS, Lienhard GE (Jul 1999). "Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains". Biochim Biophys Acta. 1431 (2): 525–30. doi:10.1016/S0167-4838(99)00068-0. PMID 10350628.

[pmid17672888-7] Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.

[entrez-8] "Entrez Gene: FAM62A family with sequence similarity 62 (C2 domain containing), member A".

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