Article · Wikipedia archive · Last revised Jul 3, 2026

Eprobemide

Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia. It is a non-competitive reversible inhibitor of monoamine oxidase A that exhibits selective action on serotonin deamination. Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.

Last revised
Jul 3, 2026
Read time
≈ 1 min
Length
210 w
Citations
5
Source
Wikipedia ↗
Eprobemide
Clinical data
Trade namesBefol (RU)
Other namesBefol
Routes of
administration		Oral
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 4-Chloro-N-[3-(4-morpholinyl)propyl]benzamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H19ClN2O2
Molar mass282.77 g·mol−1
3D model (JSmol)
  • C1COCCN1CCCNC(=O)C2=CC=C(C=C2)Cl
  • InChI=1S/C14H19ClN2O2/c15-13-4-2-12(3-5-13)14(18)16-6-1-7-17-8-10-19-11-9-17/h2-5H,1,6-11H2,(H,16,18)
  • Key:YYFGRAGNYHYWEZ-UHFFFAOYSA-N

Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia (under the brand name Бефол/Befol).1 It is a non-competitive reversible inhibitor of monoamine oxidase A23 that exhibits selective action on serotonin deamination.4 Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.5

See also

See also

References

References

  1. Ganellin CR, Triggle DJ (1996). Dictionary of Pharmacological Agents. Vol. 3. CRC Press. p. 811. ISBN 978-0412466304.
  2. Gol'dina OA, Moskvitina TA, Gankina EM, Kirkel' AZ, Kamyshanskaia NS, Lopatina KI, et al. (March 1991). "[The action of befol and its derivatives on monoamine oxidase of different origins]". Biulleten' Eksperimental'noi Biologii I Meditsiny. 111 (3): 279–80. PMID 2054504.
  3. Donskaya NS, Antonkina OA, Glukhan EN, Smirnov SK (2004-07-01). "Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine". Pharmaceutical Chemistry Journal. 0091-150X. 38 (7): 381–384. doi:10.1023/B:PHAC.0000048439.38383.5f. S2CID 29121452.
  4. "Eprobemide". ChemIDplus.
  5. "Befol". 4DOKTOR.RU Drug Information Handbook (in Russian). Retrieved 4 February 2014.