EPHA10

EPHA10
Identifiers
Aliases	EPHA10, EPH receptor A10
External IDs	OMIM: 611123; MGI: 3586824; HomoloGene: 67804; GeneCards: EPHA10; OMA:EPHA10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,765,133 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,917,800 bp
RNA expression pattern
	Top expressed in
	sperm; ; mucosa of transverse colon; ; left testis; ; right testis; ; rectum; ; mucosa of ileum; ; right frontal lobe; ; Brodmann area 9; ; nucleus accumbens; ; epithelium of colon;
	Top expressed in
	piriform cortex; ; primary visual cortex; ; superior colliculus; ; ventral tegmental area; ; superior frontal gyrus; ; pontine nuclei; ; medial vestibular nucleus; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; transmembrane-ephrin receptor activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cytoplasm; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; biological process; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	284656
	230735
	ENSG00000183317
	ENSMUSG00000028876
	Q5JZY3
	Q8BYG9
	NM_001004338; NM_001099439; NM_173641
	NM_001256432; NM_177671
	NP_001092909; NP_775912
	NP_001243361; NP_808339
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.⁵

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.⁵

References

GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.

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