DPP6

DPP6
Identifiers
Aliases	DPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDs	OMIM: 126141; MGI: 94921; HomoloGene: 22560; GeneCards: DPP6; OMA:DPP6 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XFD
Gene location (Human)
Chr.	Chromosome 7 (human)
End	154,894,285 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	27,932,503 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; pons; ; lateral nuclear group of thalamus; ; primary visual cortex; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; Region I of hippocampus proper;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; habenula; ; superior frontal gyrus; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; superior colliculus; ; supraoptic nucleus; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity;
Cellular component	integral component of membrane; plasma membrane; membrane; voltage-gated potassium channel complex;
Biological process	protein localization to plasma membrane; regulation of potassium ion transmembrane transport; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	1804
	13483
	ENSG00000130226; ENSG00000282974
	ENSMUSG00000061576
	P42658; Q8IYG9
	Q9Z218
	NM_001039350; NM_001290252; NM_001290253; NM_001936; NM_130797
	NM_001136060; NM_001198886; NM_010075; NM_207282
NP_001034439; NP_001277181; NP_001277182; NP_001927; NP_570629;
	NP_001351426; NP_001351427; NP_001351428; NP_001351429; NP_001351430; NP_001351431; NP_001277182.1; NP_570629.2; NP_001034439.1; NP_001277181.1; NP_001927.3; NP_570629.2
	NP_001129532; NP_001185815; NP_034205; NP_997165
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.⁵⁶

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.⁶

References

ENSG00000282974 GRCh38: Ensembl release 89: ENSG00000130226, ENSG00000282974 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000061576 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A. 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689.
"Entrez Gene: DPP6 dipeptidyl-peptidase 6".

Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Yokotani N, Doi K, Wenthold RJ, Wada K (1993). "Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7". Hum. Mol. Genet. 2 (7): 1037–9. doi:10.1093/hmg/2.7.1037. PMID 8103397.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kin Y, Misumi Y, Ikehara Y (2001). "Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein". J. Biochem. 129 (2): 289–95. doi:10.1093/oxfordjournals.jbchem.a002856. PMID 11173531.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nadal MS, Ozaita A, Amarillo Y, et al. (2003). "The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels". Neuron. 37 (3): 449–61. doi:10.1016/S0896-6273(02)01185-6. PMID 12575952. S2CID 11494299.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195. S2CID 36630738.
Strop P, Bankovich AJ, Hansen KC, et al. (2004). "Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family". J. Mol. Biol. 343 (4): 1055–65. doi:10.1016/j.jmb.2004.09.003. PMID 15476821.
Zagha E, Ozaita A, Chang SY, et al. (2005). "DPP10 modulates Kv4-mediated A-type potassium channels". J. Biol. Chem. 280 (19): 18853–61. doi:10.1074/jbc.M410613200. PMID 15671030.
Radicke S, Cotella D, Graf EM, et al. (2005). "Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3". J. Physiol. 565 (Pt 3): 751–6. doi:10.1113/jphysiol.2005.087312. PMC 1464568. PMID 15890703.
Ren X, Hayashi Y, Yoshimura N, Takimoto K (2005). "Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels". Mol. Cell. Neurosci. 29 (2): 320–32. doi:10.1016/j.mcn.2005.02.003. PMID 15911355. S2CID 34065803.
Jerng HH, Kunjilwar K, Pfaffinger PJ (2006). "Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties". J. Physiol. 568 (Pt 3): 767–88. doi:10.1113/jphysiol.2005.087858. PMC 1464192. PMID 16123112.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B (2006). "Differential characterization of three alternative spliced isoforms of DPPX". Brain Res. 1094 (1): 1–12. doi:10.1016/j.brainres.2006.03.106. PMID 16764835. S2CID 33513405.

[refGRCh38Ensembl-1] ENSG00000282974 GRCh38: Ensembl release 89: ENSG00000130226, ENSG00000282974 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1729689-5] Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A. 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689.

[entrez-6] "Entrez Gene: DPP6 dipeptidyl-peptidase 6".

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