Article · Wikipedia archive · Last revised Aug 6, 2026

DPI-221

DPI-221 is an opioid drug that is used in scientific research. It is a highly selective agonist for the δ-opioid receptor, which produces fewer convulsions than most drugs from this family.

Last revised
Aug 6, 2026
Read time
≈ 1 min
Length
97 w
Citations
1
Source
Wikipedia ↗
DPI-221
Identifiers
  • 4-((αS)-α-((2S,5R)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC31H38FN3O
Molar mass487.651
3D model (JSmol)
  • O=C(N(CC)CC)c1ccc(cc1)[C@@H](N3C[C@H](N(Cc2cc(F)ccc2)C[C@@H]3C)C)c4ccccc4
  • InChI=1S/C31H38FN3O/c1-5-33(6-2)31(36)28-17-15-27(16-18-28)30(26-12-8-7-9-13-26)35-21-23(3)34(20-24(35)4)22-25-11-10-14-29(32)19-25/h7-19,23-24,30H,5-6,20-22H2,1-4H3/t23-,24+,30+/m1/s1
  • Key:KEXJLZMJVOTFOY-QEGDFHJFSA-N
  (verify)

DPI-221 is an opioid drug that is used in scientific research. It is a highly selective agonist for the δ-opioid receptor, which produces fewer convulsions than most drugs from this family.1

References

References

  1. Holt JD, Watson MJ, Chang JP, O'Neill SJ, Wei K, Pendergast W, et al. (November 2005). "DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats". The Journal of Pharmacology and Experimental Therapeutics. 315 (2): 601–8. doi:10.1124/jpet.105.090498. PMID 16020629. S2CID 97486165.