DGKQ

DGKQ
Identifiers
Aliases	DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs	OMIM: 601207; MGI: 102918; HomoloGene: 20352; GeneCards: DGKQ; OMA:DGKQ - orthologs
EC number	2.7.1.107
Gene location (Human)
Chr.	Chromosome 4 (human)
End	986,895 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,817,538 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; pancreatic ductal cell; ; granulocyte; ; jejunal mucosa; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; duodenum; ; mucosa of sigmoid colon; ; thymus;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; lip; ; genital tubercle; ; neural layer of retina; ; jejunum; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; phospholipase binding; metal ion binding; kinase activity; kinase binding; protein binding; ATP binding; diacylglycerol kinase activity; transmembrane receptor protein tyrosine kinase activator activity; NAD+ kinase activity;
Cellular component	cytoplasm; cytosol; nuclear speck; membrane; plasma membrane; cytoskeleton; nucleus; endosome; vesicle membrane; nuclear matrix; presynapse; postsynapse; glutamatergic synapse;
Biological process	G protein-coupled receptor signaling pathway; thrombin-activated receptor signaling pathway; response to ATP; intracellular signal transduction; phosphorylation; regulation of transcription by RNA polymerase II; protein kinase C signaling; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; signal transduction; glycerolipid metabolic process; diacylglycerol metabolic process; lipid phosphorylation; regulation of gluconeogenesis; phosphatidic acid biosynthetic process; activation of transmembrane receptor protein tyrosine kinase activity; regulation of G protein-coupled receptor signaling pathway; positive regulation of gene expression; negative regulation of gene expression; negative regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; cAMP-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; response to cAMP; regulation of cholesterol metabolic process; regulation of TORC1 signaling; regulation of cortisol biosynthetic process; regulation of progesterone biosynthetic process; metabolism; regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1609
	110524
	ENSG00000145214
	ENSMUSG00000004815
	P52824
	Q6P5E8
	NM_001347
	NM_199011; NM_001357029
	NP_001338
	NP_950176; NP_001343958
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.⁵⁶⁷

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.⁷

Interactions

DGKQ has been shown to interact with RHOA.⁸

References

GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
"Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.

Further reading

Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. hdl:11380/801893. PMID 12799190.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617502-5] Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.

[pmid9099683-6] Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.

[entrez-7] "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".

[pmid10066731-8] Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.

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