Derlin-3

DERL3
Identifiers
Aliases	DERL3, C22orf14, IZP6, LLN2, derlin-3, derlin 3
External IDs	OMIM: 610305; MGI: 1917627; HomoloGene: 41566; GeneCards: DERL3; OMA:DERL3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,839,128 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,895,941 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; duodenum; ; tonsil; ; epithelium of colon; ; appendix; ; body of pancreas; ; lymph node; ; spleen; ; mucosa of transverse colon; ; rectum;
	Top expressed in
	salivary gland; ; submandibular gland; ; lacrimal gland; ; parotid gland; ; zygote; ; seminal vesicula; ; primary oocyte; ; secondary oocyte; ; pyloric antrum; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; signal recognition particle receptor complex; signal recognition particle;
Biological process	endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; ubiquitin-dependent ERAD pathway;
	Sources:Amigo / QuickGO
Orthologs
	91319
	70377
	ENSG00000274437; ENSG00000099958
	ENSMUSG00000009092
	Q96Q80
	Q9D8K3
	NM_001002862; NM_001135751; NM_198440; NM_001363072
	NM_024440
	NP_001002862; NP_001129223; NP_940842; NP_001350001
	NP_077760; NP_001345912; NP_001345913; NP_001345914
	Wikidata
View/Edit Human	View/Edit Mouse

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.⁵⁶

References

ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
"Entrez Gene: DERL3 Der1-like domain family, member 3".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
Wang X, Bolotin D, Chu DH, et al. (2006). "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis". J. Cell Biol. 172 (3): 409–21. doi:10.1083/jcb.200510002. PMC 2063650. PMID 16449191.
Morrison JI, Lööf S, He P, Simon A (2006). "Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population". J. Cell Biol. 172 (3): 433–40. doi:10.1083/jcb.200509011. PMC 2063652. PMID 16449193.

[refGRCh38Ensembl-1] ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15215855-5] Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.

[entrez-6] "Entrez Gene: DERL3 Der1-like domain family, member 3".

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See also

References

Further reading