Article · Wikipedia archive · Last revised Jul 3, 2026

Denopamine

Denopamine (INN) is a drug which acts as a β1 adrenergic receptor agonist. It is used in the treatment of angina and may also have potential uses in the treatment of congestive heart failure and for clearing pulmonary edema. It is marketed in Japan under the brand name Kalgut and available as tablets of 5 and 10 mg, and 5% fine granules.

Last revised
Jul 3, 2026
Read time
≈ 1 min
Length
287 w
Citations
5
Source
Wikipedia ↗
Denopamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
  • none
Legal status
Legal status
  • Rx-only (JP)
Identifiers
  • 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.163.233
Chemical and physical data
FormulaC18H23NO4
Molar mass317.385 g·mol−1
3D model (JSmol)
  • O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C

Denopamine (INN) is a drug which acts as a β1 adrenergic receptor agonist.1 It is used in the treatment of angina2 and may also have potential uses in the treatment of congestive heart failure3 and for clearing pulmonary edema.4 It is marketed in Japan under the brand name Kalgut and available as tablets of 5 and 10 mg, and 5% fine granules.5

References

References

  1. Ishide T (2002). "Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator". Current Medical Research and Opinion. 18 (7): 407–13. doi:10.1185/030079902125001119. PMID 12487507. S2CID 25048757.
  2. Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. (April 2006). "Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment". International Journal of Cardiology. 108 (2): 281–3. doi:10.1016/j.ijcard.2005.03.012. PMID 15913812.
  3. Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S (September 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". Journal of the American College of Cardiology. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223. PMID 9741531.
  4. Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. (February 2001). "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Japanese Journal of Pharmacology. 85 (2): 161–6. doi:10.1254/jjp.85.161. PMID 11286398.
  5. "Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information" (PDF) (in Japanese). Mitsubishi Tanabe Pharma Corporation. Retrieved 6 March 2016.