DCTN4

DCTN4
Identifiers
Aliases	DCTN4, DYN4, P62, dynactin subunit 4
External IDs	OMIM: 614758; MGI: 1914915; HomoloGene: 9430; GeneCards: DCTN4; OMA:DCTN4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,759,095 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	60,691,838 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; retinal pigment epithelium; ; tail of epididymis; ; corpus epididymis; ; lactiferous duct; ; pars reticulata; ; pars compacta; ; caput epididymis;
	Top expressed in
	genital tubercle; ; cumulus cell; ; pineal gland; ; tail of embryo; ; supraoptic nucleus; ; ciliary body; ; renal corpuscle; ; aortic valve; ; medullary collecting duct; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein N-terminus binding;
Cellular component	cytoplasm; cytosol; centrosome; cytoplasmic dynein complex; cytoskeleton; nucleus; dynactin complex; microtubule organizing center; kinetochore; spindle pole; stress fiber; focal adhesion; cell cortex; sarcomere;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; nuclear migration; antigen processing and presentation of exogenous peptide antigen via MHC class II;
	Sources:Amigo / QuickGO
Orthologs
	51164
	67665
	ENSG00000132912
	ENSMUSG00000024603
	Q9UJW0
	Q8CBY8
	NM_001135643; NM_001135644; NM_016221
	NM_026302; NM_001357462
	NP_001129115; NP_001129116; NP_057305
	NP_080578; NP_001344391
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin subunit 4 is a protein that in humans is encoded by the DCTN4 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000132912 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024603 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Dynactin 4 (p62)".

Further reading

Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, Gibson RL, Bamshad MJ (July 2012). "Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis". Nature Genetics. 44 (8): 886–9. doi:10.1038/ng.2344. PMC 3702264. PMID 22772370.
Ayalon G, Davis JQ, Scotland PB, Bennett V (December 2008). "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan". Cell. 135 (7): 1189–200. doi:10.1016/j.cell.2008.10.018. PMID 19109891. S2CID 17268857.
Bingham JB, Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. Bibcode:1999CBio....9..223B. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429. S2CID 208851.
Lim CM, Cater MA, Mercer JF, La Fontaine S (May 2006). "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A". The Journal of Biological Chemistry. 281 (20): 14006–14. doi:10.1074/jbc.M512745200. hdl:10536/DRO/DU:30003771. PMID 16554302.
Boultwood J, Fidler C, Strickson AJ, Watkins F, Kostrzewa M, Jaju RJ, Müller U, Wainscoat JS (May 2000). "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs". Genomics. 66 (1): 26–34. doi:10.1006/geno.2000.6193. PMID 10843801.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132912 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024603 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dynactin 4 (p62)".

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