Article · Wikipedia archive · Last revised Jul 17, 2026

DCrk

DCrk is the Drosophila melanogaster ortholog of the mammalian proteins Crk and CrkL.

Last revised
Jul 17, 2026
Read time
≈ 1 min
Length
98 w
Citations
2
Source
Wikipedia ↗
Crk oncogene
Identifiers
OrganismDrosophila melanogaster
SymbolCrk
UniProtQ95RW2
Search for
StructuresSwiss-model
DomainsInterPro

DCrk (Drosophila ortholog of Crk) is the Drosophila melanogaster ortholog of the mammalian proteins Crk and CrkL.1

Structure and function

DCrk includes one SH2 domain followed by two SH3 domains and interacts with the MyoBlast City (MCB) protein. The DCrk protein is expressed during embryogenesis, declines during the larval stages, and reappears during pupation which suggests that DCrk plays an important role in development.1

References

References

  1. Galletta BJ, Niu XP, Erickson MR, Abmayr SM (March 1999). "Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC". Gene. 228 (1–2): 243–52. doi:10.1016/S0378-1119(99)00010-4. PMID 10072777.