Article · Wikipedia archive · Last revised Jun 12, 2026

Daf-9

The daf-9 gene encodes a cytochrome p450 enzyme that catalyses the generation of dafachronic acid in the worm Caenorhabditis elegans, with the CYP Symbol CYP22A1. After generation, dafachronic acid will bind its nuclear receptor Daf-12, whose genetic mutation has been implicated by Cynthia Kenyon and colleagues as related to the formation of Dauer larva.

Last revised
Jun 12, 2026
Read time
≈ 1 min
Length
180 w
Citations
3
Source
Wikipedia ↗
Cytochrome P450 daf-9
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-9
Alt. symbolsCYP22A1
Entrez180889
RefSeq (mRNA)NM_001029732.2
RefSeq (Prot)NP_001024903.1
UniProtH2KYS3
Other data
ChromosomeX: 6.2 - 6.2 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The daf-9 gene encodes a cytochrome p450 enzyme that catalyses the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,12 with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will bind its nuclear receptor Daf-12, whose genetic mutation has been implicated by Cynthia Kenyon and colleagues as related to the formation of Dauer larva.3

References

References

  1. Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID 11782415.
  2. Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ (2006). "Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans". Cell. 124 (6): 1209–1223. doi:10.1016/j.cell.2006.01.037. PMID 16529801.
  3. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153. S2CID 4332206.